SURVEY PLASMA ANTI-THYROGLOBULIN CONCENTRATION IN MONITORING OF DIFFERENTIATED THYROID CANCER PATIENTS WITH I-131 TREATMENT AT DA NANG ONCOLOGY HOSPITAL IN VIET NAM

Thi Minh Nguyen Tran1, Thi Tuyet Thu Ho2, Thi Tuyet Ngo2, Thi Ngoc Anh Huynh2, Thi Thuy Le2,
1 Da Nang Family hospital
2 Da Nang University of Medical Technology and Pharmacy

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Abstract

Background: Thyroid cancer is a common disease and occurs when there is an abnormality in the growth of thyroid cells. Postoperative Anti Thyroglobulin may act as a biomarker for residual thyroid tissue, found more often in differentiated thyroid cancer, used to track recurrence or survival of differentiated thyroid cancer. Objectives: To determine the concentration of plasma Anti Tg and relationship between plasma Anti-Tg concentration with other factors in follow-up of thyroid cancer patients with surgery combined with I-131 treatment at Da Nang Oncology Hospital. Materials and method: The descriptive cross-sectional study on 115 people with differentiated thyroid cancer underwent full thyroid surgery in combination with the first I-131 treatment at the Department of Nuclear Medicine at Da Nang Oncology Hospital. Collected data were handled by the statistical software SPSS 20.0. Results: Anti Tg concentration in patients with differentiated thyroid cancer after treatment was statistically decreased compared to before treatment with radioactive iodine. Conclusion: It is necessary to continue to study the value of the Anti Tg test in the monitoring of patients with differentiated thyroid cancer who are treated with I-131 after surgery.

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References

1. Nguyễn Xuân Cảnh và cộng sự (2004), “Vai trò của thyroglobulin và antithyroglobulin trong theo dõi điều trị UTTG thể biệt hóa tại khoa Y học hạt nhân bệnh viện Chợ Rẫy”, Tạp chí thông tin y dược, Hội thảo quốc tế ung thư đầu – cổ và bệnh lý thần kinh, tr. 97-101.
2. Mai Trọng Khoa và cộng sự (2018), “Giá trị của Anti Thyroglobulin trong theo dõi và điều trị ung thư tuyến giáp”, Tạp chí ung thư, Trung tâm y học hạt nhân và ung bướu Bệnh viện Bạch Mai.
3. Donald S.A et al. (2014), “Prognosis of Differentiated Thyroid Cancer in Relation to Serum Thyrotropin and Thyroglobulin Antibody Status at Time of Diagnosis”, Thyroid, 24(1), pp. 35-42.
4. Feldt-Rasmussen U (2010), “Autoimmunity in differentiated thyroid cancer: significance and related clinical problems”, Hormones (Athens), pp. 109-117.
5. Gallardo et al. (2020), “SEOM clinical guideline thyroid cancer”, Clin Transl Oncol 22, pp. 223-235.
6. Haugen BR et al. (2016), “American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer”, Thyroid, 26(1), pp.1-133.
7. Jo K, Lim DJ (2018), “Clinical implications of anti-thyroglobulin antibody measurement before surgery in thyroid cancer”, Korean J Intern Med, 33(6), pp.1050-1057.
8. Karatzas T (2016), “Thyroglobulin antibodies as a potential predictive marker of papillary thyroid carcinoma in patients with indeterminate cytology”, Am J Surg, 212(5), pp. 946-952.
9. World Health Organization (2019), “Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods”,
10. , accesed September 2019.
11. Zhang T, et al. (2017), “Effect of lymph node metastasis on change of positive thyroglobulin antibody in differentiated thyroid carcinoma after initial treatment”, Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 39, pp. 539-543.