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THE STUDY SITUATION OF THE GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY IN NEWBORNS AT HOAN MY DA LAT GENERAL HOSPITAL IN VIET NAM
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Abstract
Background: Deficiency of the enzyme glucose 6 phosphate dehydrogenase (G6PD) is a common genetic disease, an autosomal recessive disorder on the X sex chromosome. Deficiency of the enzyme G6PD results in: fragile red blood cells causing acute hemolysis, jaundice in children neonate, increases the risk of nuclear jaundice, leaving permanent neurological sequelae. Objectives: Determine the rate of the enzyme G6PD deficiency and some factors associated in infants born at Hoan My Dalat General Hospital. Materials and method: This is a descriptive crosssectional study on 1000 babies born in the Obstetrics, Hoan My Dalat General Hospital from November 2019 to March 2020, tested for G6PD, blood count tests and collected a survey on maternal age, gender of the child, gestational age, weight at birth, family history of genetic disease. Collected data were handled by the statistical software SPSS 20.0. Results: The rate of the enzyme G6PD deficiency was 2.2%. There was significant association between the enzyme G6PD and sex, weight, concentration hemoglobin There was no correlation of G6PD enzyme with geography, maternal age, age pregnancy. Conclusion: Newborn screening for G6PD deficiency should be performed in all infants birth in a medical setting for early detection and consequent prevention measures disease appropriate.
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Keywords
Glucose 6 phosphate dehydrogenase, infant, blood count test
References
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