Article Sidebar
Views PDF: 208
THE STUDY SITUATION OF THE GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY IN NEWBORNS AT HOAN MY DA LAT GENERAL HOSPITAL IN VIET NAM
Main Article Content
Abstract
Background: Deficiency of the enzyme glucose 6 phosphate dehydrogenase (G6PD) is a common genetic disease, an autosomal recessive disorder on the X sex chromosome. Deficiency of the enzyme G6PD results in: fragile red blood cells causing acute hemolysis, jaundice in children neonate, increases the risk of nuclear jaundice, leaving permanent neurological sequelae. Objectives: Determine the rate of the enzyme G6PD deficiency and some factors associated in infants born at Hoan My Dalat General Hospital. Materials and method: This is a descriptive crosssectional study on 1000 babies born in the Obstetrics, Hoan My Dalat General Hospital from November 2019 to March 2020, tested for G6PD, blood count tests and collected a survey on maternal age, gender of the child, gestational age, weight at birth, family history of genetic disease. Collected data were handled by the statistical software SPSS 20.0. Results: The rate of the enzyme G6PD deficiency was 2.2%. There was significant association between the enzyme G6PD and sex, weight, concentration hemoglobin There was no correlation of G6PD enzyme with geography, maternal age, age pregnancy. Conclusion: Newborn screening for G6PD deficiency should be performed in all infants birth in a medical setting for early detection and consequent prevention measures disease appropriate.
Article Details
Keywords
Glucose 6 phosphate dehydrogenase, infant, blood count test
References
2. Nguyễn Thị Kiều Oanh và cộng sự, “Kết quả sàng lọc thiếu enzyme G6PD và suy giáp bẩm sinh và các yếu tố liên quan ở trẻ sơ sinh tại Bệnh viện Đại học Y Dược cơ sở 2, Thành phố Hồ Chí Minh”, 2019, Tạp chí Y Học TP.Hồ Chí Minh, 23(5), tr. 287-293
3. Boonyuen U., Chamchoy K., Swangsri T., et al, “Detailed functional analysis of two clinical glucose 6 phosphate dehydrogenase (G6PD) variants, enzyme G6PDViangchan and enzyme G6PDViangchan+Mahidol: Decreased stability and catalytic efficiency contribute to the clinical phenotype”, Mol Genet Metab, 2016, 118(2), pp. 84-91.
4. Fu C, Luo S, Li Q, Xie B, Yang Q, Geng G, et al, “Newborn screening of glucose 6 phosphate dehydrogenase deficiency in Guangxi, China: determination of optimal cutoff value to identify heterozygous female neonates”, Sci Rep, 2018, 8 (1), pp. 833.
5. Jennifer E. Frannk, “Diagnosis and manageenzymet of G6PD deficiency”, American Family Physician, 2005, 72 (7), pp. 1277-1282.
6. Jing Zhang, Yali Cui, et al., “Prevalence of glucose 6 phosphate dehydrogenase deficiency in Sichuan, China”, 2018, 64(3), pp. 383-386.
7. Sukamal Bisoi, Sumanta Chakraborty, et al, ”Glucose 6 phosphate dehydrogenase screening of babies born in a tertiary care hospital in West Bengal”, 2012, 56(2), pp. 146-148.
8. Tang F., Huang Y. L., Jiang X., et al., “Evaluations of newborn screening program performance and enzymatic diagnosis of glucose 6 phosphate dehydrogenase deficiency in Guangzhou”, Zhonghua Er Ke Za Zhi, 2018, 56 (5), pp. 359-363.
9. WHO Working Group, “glucose 6 phosphate dehydrogenase deficiency”, Bull WHO, 67(6), pp. 601–611.
10. Yang H., Wang Q., Zheng L., et al. “Incidence and molecular characterization of glucose 6 phosphate dehydrogenase deficiency among neonates for newborn screening in Chaozhou, China”, Int J Lab Hematol, 2015, 37 (3), pp. 410-419.