ĐẶC ĐIỂM GÂY BỆNH VÀ TÍNH KHÁNG KHÁNG SINH CỦA PSEUDOMONAS AERUGINOSA TẠI BỆNH VIỆN C ĐÀ NẴNG

Abstract

 Background: P.aeruginosa is one of the causative agents of severe multi-organ infections. Bacteria have diverse resistance mechanisms, so they tend to be resistant to many different antibiotic strains, thus causing many difficulties in treatment. Objective: Investigation of pathogenic characteristics and antibiotic resistance of P.aeruginosa at Da Nang C Hospital. Materials and method: A cross-sectional study on 43 strains of P.aeruginosa isolated from sputum, bronchial fluid, blood, urine, and pus at Hospital C Da Nang. Determination of antibiotic resistance of P.aeruginosa strains by Kirby-Bauer method. Classification of the degree of multi-antibiotic resistance of bacteria causing infections was performed according to Magiorakos et al. Results: Ratio of P.aeruginosa causing infection in men and women was 62.8%, and 32.7%. P.aeruginosa infections mainly in elderly patients aged 60 years and older, accounting for 83,7%. The most isolated strains of P.aeruginosa were found in the Intensive Care Unit (41.9%), the Department of Respiratory Medicine (18.6%), the Department of Internal Medicine Geriatrics (13.9%), the Department of General Surgery (9.3%), Neuro-Trauma Surgery (9.3%) and the lowest in the Department Renal Internal (7%). The highest form of clinical infection caused by P. aeruginosa is respiratory infection (60.5%), followed by urinary tract infection (16.3%), wound infection (9.3%), surgical site infection (2.3%), ulcer infection (9.3%) and blood infection (2.3%). P.aeruginosa was isolated from sputum (51.2%), pus (20.9%), urine (16.3%), bronchial fluid (9.3%) and at least in blood (2.3%). P.aeruginosa has low resistance to Colistin, Piperacillin/Tazobactam, Amikacin with the rate of 16.3%, respectively; 11.6%; 32.6%, resistance ranges from 40-60% to antibiotics: Torbramycin and Gentamycin (44.2%), Cefepime (46.5%), Ciprofloxacin (53.5%), Meropenem (44.2). %), Imipenem (41.9%), Levofloxacin (55.8%), Ofloxacin (58.1%). There were 23.3% multiresistant P.aeruginosa, 30.2% extended resistance and no fully resistant strains. Conclusions: P.aeruginosa causes infections mainly in males and in elderly patients. Respiratory infection is the most common form of infection caused by P. aeruginosa. The most isolated samples of P.aeruginosa were sputum, followed by pus and urine. Bacteria are relatively resistant from 40-60% to the antibiotics Ciprofloxacin, Meropenem, Imipenem, Levofloxacin, Ofloxacin. There were 23.3% multi-resistant P.aeruginosa strains, 30.2% extended resistance strains and no all-resistant strains.