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Date Published: 15/04/2023
Online Published: 15/04/2023
Abstract Views: 324
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DOI: https://doi.org/10.58490/ctump.2023i58.700
Issue
No. 58 (2023): HỘI NGHỊ KHOA HỌC QUỐC TẾ MỞ RỘNG LẦN THỨ II NĂM 2023
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Article
How to Cite
Ngo, T. N., Nguyen, T. T., Le, T. B. T., Nguyen, T. T., & Hoang, T. H. S. (2023). STUDY ON DIURETIC EFFECT OF EXTRACTS OF CLINACANTHUS NUTANS (ACANTHACEAE) LEAF IN MICE. Cantho Journal of Medicine and Pharmacy, 58, 114-121. https://doi.org/10.58490/ctump.2023i58.700

STUDY ON DIURETIC EFFECT OF EXTRACTS OF CLINACANTHUS NUTANS (ACANTHACEAE) LEAF IN MICE

Thi Nga Ngo1,, Thi Thuong Nguyen1, Thi Bich Thuy Le1, Thanh Thao Nguyen1, Thi Hoang Sa Hoang1
1 Da Nang University of Medical Technology and Pharmacy

Main Article Content

Abstract

Background: Clinacanthus nutans leaves have been used to support the treatment of urinary incontinence. Objectives: Evaluate effect of extracts of clinacanthus nutans leaves on volume and electrolytes concentration of urine. Materials and methods: 36 Swiss albino mice were orally administered distilled water, water extract, alcoholic extract of clinacanthus nutans leaves or furosemide. Urine volumn of mice was measured after 1,2,3,4,5, and 24 hours. Total 24-hour urine was analysed electrolytic concentration. Results: The urine volume of group administered clinacanthus nutans leaves extracts was increased after 5 hours (p<0.05). Urine Na+ and Cl- concentration of group administrated clinacanthus nutans leaves extracts increased significantly (p<0.05). Urine K+ concentration of group administrated alcoholic extract at the dose of 2000 mg/kg was significantly (p<0.05) lower than that of group administrated furosemide. Conclusions: CNL extracts increase the urine volume and salt excretion. Alcohol extract of clinacanthus nutans leaves at the dose of 2000 mg/kg reduced hypokalaemic than furosemide.    

Article Details

Keywords

Clinacanthus nutans, furosemid, diuretic effect

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