RISH FACTORS FOR BRONCHOPULMONARY DYSPLASIA IN VERY PRETERM INFANTS

Hoang Minh Chau Le1,, Van Hieu Mai2, Thi Dieu Nguyen3, Thi Hoang Tran1,3
1 Da Nang Medical Technology and Pharmacy
2 Viet Nam National University Ho Chi Minh City
3 Da Nang Hospital for Women and Children

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Abstract

Background: Bronchopulmonary dysplasia is a common complication in very preterm infants. Objectives: To determine risk factors of bronchopulmonary dysplasia in very preterm infants. Materials and method: This is a cross-sectional study on 170 newborns less than 32 gestational age, admitted to the neonatal unit at Da Nang Hospital for Women and Children from 01/02/2019 to 31/1/2020. Maternal history, demographic features, and morbidities of newborns during hospitalization was collected. Multivariate regression was used to determine independent risk factors for bronchopulmonary dysplasia. Results: 54/170 infants (31.8%) had BPD. Gestational age less than 28 weeks (OR 7.85; 95% CI 3.50-17.75), birth weight less than 1000g (OR 5.17; 95% CI 2.37-11.31), normal vaginal delivery (OR 2.99; 95% CI 1.31-7.31), severe anemia (OR 33.14; 95% CI 7.92-288.97), sepsis (OR 51.20; 95% CI 8.08-2095.04), intraventricular haemorrhage (OR 4.03; 95% CI 1.91-8.66), poor weight gain (OR 2.94; 95% CI 1.34-6.76), and patent ductus arteriosus (OR 11.54; 95% CI 5.03-27.24) related to BPD (p<0.05). There was only patent ductus arteriosus as an independent risk factor for bronchopulmonary dysplasia in very preterm infants  (OR 3.40; 95%CI 1.32-8.73) (p<0.05). Conclusion: The prevalence of bronchopulmonary dysplasia is high, and patent ductus arteriosus increases the risk of bronchopulmonary dysplasia in very preterm infants.  

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References

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