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Date Published: 15/04/2023
Online Published: 24/04/2023
Abstract Views: 199
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DOI: https://doi.org/10.58490/ctump.2023i58.688
Issue
No. 58 (2023): HỘI NGHỊ KHOA HỌC QUỐC TẾ MỞ RỘNG LẦN THỨ II NĂM 2023
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Article
How to Cite
Vo, H. H., & Vo, T. N. (2023). INVESTIGATION OF HUMORAL IMMUNE DISORDERS IN CHILDREN WITH SEPSIS IN PEDIATRIC INTENSIVE CARE UNITAT DA NANG HOSPITAL FOR WOMEN AND CHILDREN. Cantho Journal of Medicine and Pharmacy, 58, 20-26. https://doi.org/10.58490/ctump.2023i58.688

INVESTIGATION OF HUMORAL IMMUNE DISORDERS IN CHILDREN WITH SEPSIS IN PEDIATRIC INTENSIVE CARE UNITAT DA NANG HOSPITAL FOR WOMEN AND CHILDREN

Huu Hoi Vo1,, Tan Nga Vo1
1 Da Nang Hospital for Women and Children

Main Article Content

Abstract

Background: Sepsis has a complex pathophysiology with several diverse and nonspecific mechanisms. Objectives: To investigate humoral immune disorders and the correlation between immunoglobulin levels and some clinical, subclinical characteristics and 28-day mortality in children with sepsis. Materials and method: A descriptive cross - sectional study of 91 children with sepsis treated in Pediatric Intensive Care Unit in Da Nang Hospital for Women and Children from January 2020 to January 2022. Collecting blood samples to evaluate IgG, IgM, IgA, IgE levels at the time when children were just diagnosed with sepsis. Assessing some clinical symptoms and subclinical characteristics and following up children up to 28 days to record the treatment results (survival or death). Results: The number of children with low levels of IgG, IgM, IgA accounted for 25.3%, 14.3% and 15.4%, respectively. The percentage of pediatric patients with high levels of IgG, IgM, IgA, IgE was 38.4%; 26.4%; 20.9% and 11.0%, respectively. There was a statistically significant difference between septic shock, multiorgan dysfunction syndrome with IgG and IgM levels, p < 0.05. There was no difference in 28-day mortality between two groups of low and high IgG levels (p > 0.05). Conclusion: There were humoral immune disorders in children with sepsis, but the levels of immunoglobulins had no predictive values for 28-day mortality.

Article Details

Keywords

Immunoglobulins, mortality, sepsis

References

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