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Date Published: 12/07/2023
Online Published: 12/07/2023
Abstract Views: 232
Views PDF: 202
DOI: https://doi.org/10.58490/ctump.2023i61.683
Issue
No. 61 (2023): HỘI NGHỊ THƯỜNG NIÊN HỌC VIÊN – SINH VIÊN NGHIÊN CỨU KHOA HỌC NĂM 2023
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Article
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Nguyen , T. K. N., Tran, V. A., Huynh, T. A., & Pham, T. N. N. (2023). EVALUATING CYP2C19 GENE POLYMORPHISMS AND INFLAMMATORY CELL RATIOS IN PROGNOSIS MAJOR ADVERSE CARDIAC EVENTS IN ACUTE CORONARY SYNDROME. Cantho Journal of Medicine and Pharmacy, 61, 343-350. https://doi.org/10.58490/ctump.2023i61.683

EVALUATING CYP2C19 GENE POLYMORPHISMS AND INFLAMMATORY CELL RATIOS IN PROGNOSIS MAJOR ADVERSE CARDIAC EVENTS IN ACUTE CORONARY SYNDROME

Tran Khuong Nha Nguyen 1,, Viet An Tran1, Tuan An Huynh1, Thi Ngoc Nga Pham1
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: CYP2C19 gene polymorphisms and inflammatory cell ratios are promised to be new markers in prognosis MACE in acute coronary symdrome. Objectives: To evaluate the prognostic value of CYP2C19 gene polymorphisms and inflammatory cell ratios in acute coronary syndrome. Method: This is a prospective study conducted at Can Tho University of Medicine and Pharmacy hospital. We enrolled 49 ACS patients and collected CYP2C19 genotypes and inflammatory cell ratios. The incidence of major adverse cardiovascular diseases (MACEs) during follow-up were determined. Results: Percentage of LOF allele was 53,1%. During the follow-up period, 14 MACEs occurred. Kaplain Meier showed that the incident of MACE was higher in LOF allele carriers with no significant difference. NLR, PLR, MPVLR all had significant predictive value for MACE (p<0,05). Conclusion: CYP2C19 gene polymorphisms *2,*3 may increase the incident of MACE. NLR, PLR, MPVLR were proved to be easily, low cost calculated predictors of MACE in patients with ACS. 

Article Details

Keywords

CYP2C19, inflammatory cell ratios, prognosis, major adverse cardiac events, acute coronary syndrome

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