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Date Published: 12/07/2023
Online Published: 12/07/2023
Abstract Views: 391
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DOI: https://doi.org/10.58490/ctump.2023i61.631
Issue
No. 61 (2023): HỘI NGHỊ THƯỜNG NIÊN HỌC VIÊN – SINH VIÊN NGHIÊN CỨU KHOA HỌC NĂM 2023
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Article
How to Cite
Huynh, N. H. P., Do, V. H., Truong, P., & Vo, T. C. V. (2023). SYNTHESIS AND EVALUATION OF ANTIBACTERIAL, ANTIFUNGAL, CYTOTOXIC ACTIVITIES OF SOME ASYMMETRIC 2-METHYLIMIDAZOLE-4,5-DICARBOXAMIDE DERIVATIVES. Cantho Journal of Medicine and Pharmacy, 61, 369-377. https://doi.org/10.58490/ctump.2023i61.631

SYNTHESIS AND EVALUATION OF ANTIBACTERIAL, ANTIFUNGAL, CYTOTOXIC ACTIVITIES OF SOME ASYMMETRIC 2-METHYLIMIDAZOLE-4,5-DICARBOXAMIDE DERIVATIVES

Nguyen Hoai Phuong Huynh1,, Viet Hoang Do1, Phuong Truong1, Võ Thị Cẩm Vân1
1 University of Medicine and Pharmacy at Ho Chi Minh City

Main Article Content

Abstract

Background: Imidazole is a heterocyclic structure that has been received much attention in pharmaceutical chemistry and has been appeared in many compounds with antibacterial, antifungal, antiviral, anticancer, analgesic, and anti-inflammatory activities. We chose to study 2-methylimidazole-4,5-dicarboxamide and evaluate the antibacterial, antifungal, cytotoxic activities of those derivatives. Objectives: Synthesis of asymmetric 2-methylimidazole-4,5-dicarboxamides and screening the antibacterial, antifungal, cytotoxic activitives of these derivatives. Materials and methods: The asymmetric 2-methylimidazole-4,5-dicarboxamides were synthsized from 2-methylbenzimidazole through 2 steps: Sythesis of imidazole dicarboxylic acid and synthesis of diamid. The structures of all synthethic compounds were confirmed by melting point, IR spectrum, MS spectrum, 1H-NMR spectrum. The antibacterial, antifungal activity was screened using well diffusion method on agar. The cytotoxic activity was screening using MTT method. Results: Four asymmetric 2-methylimidazole-4,5-dicarboxamides were synthesized with medium yields (25-37% for the last step). These compounds showed no antibacterial and antifungal activities on tested species. They also showed no cytotoxic activity. Conclusion: Four asymmetric 2-methylimidazole-4,5-dicarboxamides have no antibacterial and antifungal activities on tested species and no cytotoxic activities on tested cell lines.

Article Details

Keywords

Asymmetric 2-methylimidazole-4,5-dicarboxamide, antibacterial, antifungal, cytotoxic

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