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Date Published: 12/07/2023
Online Published: 17/07/2023
Abstract Views: 487
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DOI: https://doi.org/10.58490/ctump.2023i61.553
Issue
No. 61 (2023): HỘI NGHỊ THƯỜNG NIÊN HỌC VIÊN – SINH VIÊN NGHIÊN CỨU KHOA HỌC NĂM 2023
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Article
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Duong, P. T., Nguyen, T. H. Y., Nguyen, T. B. H., Quach, L. T. T., Ngo, G. T., Tran, N. P., & Cao, T. T. H. (2023). INVESTIGATION OF MIC OF COLISTIN ON BETA-LACTAM AND QUINOLONE RESISTANT ENTEROBACTERIACEAE, PSEUDOMONAS AERUGINOSA BACTERIA RESISTANT TO COLISTIN AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL IN 2022-2023. Cantho Journal of Medicine and Pharmacy, 61, 253-259. https://doi.org/10.58490/ctump.2023i61.553

INVESTIGATION OF MIC OF COLISTIN ON BETA-LACTAM AND QUINOLONE RESISTANT ENTEROBACTERIACEAE, PSEUDOMONAS AERUGINOSA BACTERIA RESISTANT TO COLISTIN AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL IN 2022-2023

Phuoc Trung Duong1,, Thi Hai Yen Nguyen1, Thi Be Hai Nguyen1, Le Thanh Thanh Quach1, Gia Thu Ngo1, Ngoc Phung Tran1, Thi Thu Hien Cao1
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Determine the minimum temperature to inhibit the growth of Colistin antibiotic to minimize the side effects of Colistin antibiotic affecting patients. Objectives: (1) To determine the rate of resistance to Beta-lactams and Quinolones of Enterobacteriaceae bacteria; rate of Colistin resistance of Pseudomonas aeruginosa strains. (2) To determine of Minimum Inhibitory Concentration (MIC) of Colistin by Broth disk elution method on Enterobacteriaceae resistant to Beta-lactams and Quinolones; Pseudomonas aeruginosa bacteria resistant to Colistin on an automated antibiogram. Materials and methods: In 208 strains of Enterobacteriaceae and P. aeruginosa bacteria causing bacterial infections, identified, and made as antibiograms according to the automatic antibiotic chart method, there were 77 resistant bacterial strains identified MIC of Colistin using Broth dis elution method. Results: Among 208 bacterial strains isolated, 77 strains (37%) showed antibiotic resistance, 53/164 (33%) Enterbacteriaceae strains showed resistance to Beta-lactam and Quinolone antibiotics; 24/44 (54.5%) bacteria Pseudomonas aeruginosa showed resistance to Colistin antibiotic. Among 77 resistant bacteria strains studied, 3 strains of bacteria with MIC of Colistin ≥4g/mL were detected: Proteus spp. showed the highest resistance with 75% (3/4), followed by Pseudomonas aeruginosa with 16.7% (4/24) and finally Klebsiella spp. with 13% (3/23) Conclusions: The rate of resistance to beta-lactam and quinolone antibiotics of Enterobacteriaceae is 32.3%; the colistin resistance rate of Pseudomonas aeruginosa strain is 54.5%. Proteus strains with MIC of Colistin ≥4g/mL accounted for the highest proportion with 75%.

Article Details

Keywords

Colistin, Pseudomonas aeruginosa, Enterobacteriaceae

References

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