NGHIÊN CỨU TÌNH HÌNH VÀ ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ NẤM DA DERMATOPHYTES BẰNG ITRACONAZOLE UỐNG KẾT HỢP KETOCONAZOLE BÔI TẠI CHỖ TẠI BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ VÀ BỆNH VIỆN DA LIỄU THÀNH PHỐ CẦN THƠ NĂM 2021-2022

Abstract

Background: Dermatophytosis is the most common superficial fungal infection caused by dermatophytes. Objectives: Study the rates of dermatophytosis and evaluate the results of itraconazole combined with ketoconazole treatment for dermatophyte infections. Materials and methods: A descriptive cross-sectional study of 153 patients with a fungal skin infection treated with itraconazole at a dose of 100 mg orally twice daily in combination with topical ketoconazole for four weeks for patients with dermatophyte infections. Results: The average age of fungal skin disease was 39.96±19.47 years old, and men were more affected than women with a ratio of 1.47:1. The highest rate of septal mycelium infection was 62.7% and was treated by a dermatologist at least 15.6%. Frequent contact with soil, animals, collective lifestyle, sharing towels, regular contact with water, wearing tight clothing, applying antifungal medication, corticosteroids, and excessive sweating can be related to septal mycelium (p<0.05). After four weeks of treatment, most patients with cured results accounted for 93.8%, and no response was 6.2% (p<0.001). Conclusions: The combination of oral itraconazole and topical ketoconazole is a cost-effective and easy-to-implement treatment option for fungal skin infections.