KHẢO SÁT ĐẶC ĐIỂM ĐA HÌNH GEN ANRIL Ở BỆNH NHÂN HỘI CHỨNG ĐỘNG MẠCH VÀNH MẠN TẠI CẦN THƠ NĂM 2025 - 2026

Abstract

Background: Single nucleotide polymorphisms (SNPs) within the ANRIL gene, have been suggested to be associated with CCS. However, data regarding the distribution of these polymorphisms in Vietnamese patients remain limited. Objectives: To investigate the frequencies of three ANRIL polymorphisms (rs1333040, rs1333049, and rs2383207) and their cardiovascular related factors in patients with chronic coronary syndrome. Materials and methods: A crosssectional descriptive study was conducted in 148 patients diagnosed with chronic coronary syndrome at 5 hospitals in Can Tho City from 2025 to 2026. Clinical characteristics, laboratory findings, and cardiovascular risk factors were collected using a standardized questionnaire. Results: The mean age of the study population was 60.06 ± 9.86 years, and 62.2% of participants were male. The genotype frequencies of rs1333040 were TT 33.1%, CT 43.9%, and CC 23.0%; for rs1333049, GG 43.9%, GC 43.2%, and CC 12.8%; and for rs2383207, GG 38.5%, GA 45.9%, and AA 15.5%. Multivariable logistic regression demonstrated that, for rs1333040, the dominant genetic model was significantly associated with physical inactivity (OR = 3.87, 95% CI: 1.07-13.98; p = 0.039), hypertension (OR = 3.79, 95% CI: 1.50-9.56; p = 0.005), and dyslipidemia (OR = 3.46, 95% CI: 1.39-8.66; p = 0.008). Under the recessive model, rs1333049 was significantly associated with hypertension (OR = 2.62, 95% CI: 1.24-5.56; p = 0.012), whereas rs2383207 was significantly associated with physical inactivity (OR = 3.17, 95% CI: 1.45-6.93; p = 0.004). Conclusions: The rs1333040, rs1333049, and rs2383207 polymorphisms of the ANRIL gene are commonly distributed among Vietnamese patients with chronic coronary syndrome. Certain genetic models were associated with modifiable cardiovascular risk factors.