PREVALENCE OF THE CHI3L1 rs4950928 POLYMORPHISM AND FACTORS ASSOCIATED WITH ASTHMA CONTROL IN PATIENTS WITH ASTHMA
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Abstract
Background: Asthma is a respiratory disease characterized by chronic inflammation. The CHI3L1 gene plays a crucial role in these respiratory injuries through Th2-mediated immune responses. However, research regarding the CHI3L1 rs4950928 polymorphism and its association with the level of asthma control remains limited. Objectives: 1. To determine the prevalence of the CHI3L1 rs4950928 polymorphism in patients with bronchial asthma; 2. To identify factors associated with the level of asthma control in these patients. Materials and methods: A cross-sectional descriptive study was conducted on 134 asthma patients managed at Tay Ninh Tuberculosis and Lung Disease Hospital. Data were collected via questionnaires, and the CHI3L1 rs4950928 polymorphism was determined using the RFLP-PCR technique from May 2025 to May 2026. Results: The mean age was 58.9 ± 12.4 years, and partially controlled asthma was the most common level at 52.6%. The rs4950928 polymorphism was predominantly represented by the CC genotype (79.1%), which is consistent with the genetic characteristics of Asian populations. Smoking was significantly associated with uncontrolled asthma. The presence of at least one G allele (CG+GG group) showed a statistically significant association with uncontrolled asthma. Logistic regression analysis confirmed that carrying the G allele (CG or GG genotype) is an independent risk factor hindering the achievement of asthma control. Conclusions: The CHI3L1 rs4950928 polymorphism is characterized by a predominance of the CC genotype. Significant associations exist between asthma control and both smoking habits and the CG/GG genotypes. The CG and GG genotypes serve as independent risk factors for uncontrolled asthma.
Keywords
CHI3L1 rs4950928 polymorphism, bronchial asthma, asthma control level
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