CHARACTERISTICS OF COAGULATION DISORDERS AND SOME RELATED FACTORS IN PATIENTS WITH ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AT CAN THO CENTRAL GENERAL HOSPITAL IN 2024-2026
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Abstract
Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) not only aggravates respiratory failure but may also be accompanied by coagulation disorders related to systemic inflammatory responses, thereby contributing to an increased risk of thrombosis during the acute clinical episode. However, data on the characteristics of coagulation disorders in patients with AECOPD in Vietnam remain limited, especially in hospitalized patients requiring clinical assessment and laboratory evaluation during hospitalization and initial management. Objective: To describe the characteristics of coagulation disorders and to identify some related factors in patients with AECOPD. Materials and methods: A cross-sectional descriptive study was conducted on 165 patients hospitalized due to AECOPD. Results: The study population was predominantly male, accounting for 97.6% of all included patients. The mean age was 71.68 ± 9.51 years, with 78.2% of patients aged 65 years or older and 52.7% having smoking history. Elevated fibrinogen and Ddimer levels were both observed in 58.8% of patients, suggesting that these were the most common coagulation abnormalities in the study population. Abnormalities in prothrombin time (PT) and activated partial thromboplastin time (aPTT) were uncommon. Univariate analysis showed that current smoking status and C-reactive protein (CRP) ≥ 1 mg/dL were significantly associated with elevated fibrinogen and D-dimer levels. In the multivariable logistic regression model, current smoking status and CRP ≥ 1 mg/dL were independent factors associated with elevated fibrinogen levels, with ORs of 4.594 and 6.928, respectively. For elevated D-dimer levels, current smoking status was an independent associated factor, with an OR of 3.784. Conclusions: Coagulation disorders in patients with AECOPD predominantly reflected a hypercoagulable profile, characterized mainly by elevated fibrinogen and D-dimer levels. Smoking history was independently associated with both elevated fibrinogen and elevated D-dimer levels, whereas CRP ≥ 1 mg/dL was independently associated with elevated fibrinogen levels only.
Keywords
AECOPD, coagulation disorders, fibrinogen, D-dimer
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