CHARACTERISTICS AND ROLES OF THE HUMAN SKIN MICROBIOME
Main Article Content
Abstract
Human skin is the largest organ of the body and serves as a habitat for a diverse community of microorganisms, including bacteria, fungi, viruses, and parasites. The skin microbiome exists in a symbiotic relationship with the host and plays a crucial role in maintaining skin barrier integrity, regulating immune responses, and protecting against pathogenic microorganisms. Advances in nextgeneration sequencing technologies have significantly improved our understanding of the biological and pathological roles of the skin microbiome. Increasing evidence indicates that dysbiosis of the skin microbiome is closely associated with the pathogenesis of common dermatological diseases such as acne vulgaris, atopic dermatitis, psoriasis, and seborrheic dermatitis. This narrative review aims to summarize current domestic and international studies on the characteristics, functions, and roles of the human skin microbiome, analyze achievements and limitations of existing research, and discuss future research trends and potential clinical applications.
Keywords
Skin microbiome, skin barrier, dermatological diseases
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References
2. Belkaid Y, Segre JA. Dialogue between skin microbiota and immunity. Science. 2014. 346(6212), 954–959. DOI: 10.1126/science.1260144.
3. Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011. 9(4), 244–253. DOI: 10.1038/nrmicro2537.
4. Kong HH. Skin microbiome: genomics-based insights into the diversity and role of skin microbes. Trends Mol Med. 2011. 17(6), 320–328. DOI: 10.1016/j.molmed.2011.01.013.
5. Sanford JA, Gallo RL. Functions of the skin microbiota in health and disease. Semin Immunol. 2013. 25(5), 370–377. DOI: 10.1016/j.smim.2013.09.005.
6. Findley K, Oh J, Yang J, Conlan S, Deming C, Meyer JA, et al. Topographic diversity of fungal and bacterial communities in human skin. Nature. 2013. 498(7454), 367–370. DOI: 10.1038/nature12171.
7. Byrd AL, Belkaid Y, Segre JA. The human skin microbiome. Nat Rev Microbiol. 2018. 16(3), 143–155. DOI: 10.1038/nrmicro.2017.157.
8. Chen YE, Fischbach MA, Belkaid Y. Skin microbiota–host interactions. Nature. 2018. 553(7689), 427–436. DOI: 10.1038/nature25177.
9. Eyerich K, Eyerich S, Biedermann T. The role of Th17 cells in inflammatory skin diseases. J Invest Dermatol. 2017. 137(4), 787–792. DOI: 10.1016/j.jid.2016.11.031.
10. Oh J, Byrd AL, Park M, Program NCS, Kong HH, Segre JA. Temporal stability of the human skin microbiome. Cell. 2016, 165(4), 854–866. DOI: 10.1016/j.cell.2016.04.008.
11. Dréno B, Araviiskaia E, Berardesca E, Bieber T, Hawk J, Sanchez Viera M, et al. The science of the skin microbiome and its role in dermatology. J Eur Acad Dermatol Venereol. 2016. 30(12), 2053–2060. DOI: 10.1111/jdv.13906.
12. Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA. 2010. 107(26), 11971–11975. DOI: 10.1073/pnas.1002601107.
13. Naik S, Bouladoux N, Linehan JL, Han SJ, Harrison OJ, Wilhelm C, et al. Commensal– dendritic-cell interaction specifies a unique protective skin immune signature. Nature. 2015. 520(7545), 104–108. DOI: 10.1038/nature14052.
14. Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, et al. Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury. Nat Med. 2009. 15(12), 1377–1382. DOI: 10.1038/nm.2062.
15. Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, et al. A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes. Immunity. 2015. 43(5), 1011–1021. DOI: 10.1016/j.immuni.2015.10.016.
16. Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T, et al. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Sci Transl Med. 2017. 9(378), eaah4680. DOI: 10.1126/scitranslmed.aah4680.
17. Dréno B, Pécastaings S, Corvec S, Veraldi S, Khammari A, Roques C. Cutibacterium acnes and acne vulgaris: a brief look at the latest updates. J Eur Acad Dermatol Venereol. 2018. 32(2), 5– 14. DOI: 10.1111/jdv.15043.
18. Eyerich S, Eyerich K, Traidl-Hoffmann C, Biedermann T. Cutaneous barriers and skin immunity. Trends Immunol. 2018. 39(4), 315–327. DOI: 10.1016/j.it.2018.01.004.
19. Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in atopic dermatitis. Genome Res. 2012. 22(5), 850–859. DOI: 10.1101/gr.131029.111.
20. Faergemann J. Management of seborrheic dermatitis and pityriasis versicolor. Am J Clin Dermatol. 2000. 1(2), 75–80. DOI: 10.2165/00128071-200001020-00001.
21. O’Neill AM, Gallo RL. Host–microbiome interactions and recent progress into understanding the biology of acne vulgaris. Microbiome. 2018.6, 177. DOI: 10.1186/s40168-018-0558-5.
22. Borda LJ, Wikramanayake TC. Seborrheic dermatitis and dandruff. J Clin Investig Dermatol. 2015. 3(2), 10. DOI: 10.13188/2373-1044.1000019.
23. Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression. Nat Rev Neurosci. 2008.9(1), 46–56. DOI: 10.1038/nrn2297.
24. Ridaura VK, Belkaid Y. Gut microbiota: the link to your second brain. Cell. 2015.161(2), 193– 194. DOI: 10.1016/j.cell.2015.03.033.
25. Myles IA, Earland NJ, Anderson ED, Moore IN, Kieh MD, Williams KW, et al. Topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis. JCI Insight. 2018. 3(9), e120608. DOI: 10.1172/jci.insight.120608.
26. Lloyd-Price J, Abu-Ali G, Huttenhower C. The healthy human microbiome. Genome Med. 2016. 8, 51. DOI: 10.1186/s13073-016-0307-y.
27. Knackstedt R, Knackstedt T, Gatherwright J. The role of topical probiotics on skin conditions. Exp Dermatol. 2020. 29(1), 15–21. DOI: 10.1111/exd.14011.
28. Claesen J, Spagnolo JB, Ramos SF, Kurita KL, Byrd AL, Aksenov AA, et al. A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles. Nature. 2020. 578(7794), 215–220. DOI: 10.1038/s41586-019-1990-4.
29. Flowers L, Grice EA. The skin microbiota: balancing risk and reward. Cell Host Microbe. 2020. 28(2), 190–200. DOI: 10.1016/j.chom.2020.06.017.
30. Chen YE, Tsao H. The skin microbiome: current perspectives and future challenges. J Am Acad Dermatol. 2013. 69(1), 143–155. DOI: 10.1016/j.jaad.2013.01.016.