DESCRIPTION OF CLINICAL AND PARACLINICAL AND RELATED FACTORS OF KNEE OSTEOARTHRITIS PATIENTS UNDERGOING TOTAL KNEE REPLACEMENT SURGERY AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL IN 2023-2024

Huynh Thuy Anh Nguyen1, , Le Hoan Nguyen1,2, Thi Kim Dan Nguyen1, Kha Ai Pham1, Phuc Thinh Le1, My Khuyen Le1
1 Can Tho University of Medicine and Pharmacy
2 Can Tho University of Medicine and Pharmacy Hospital

Main Article Content

Abstract

Background: Knee osteoarthritis is a progressive degenerative joint disease and a leading cause of reduced mobility and disability among the elderly. Total knee arthroplasty (TKA) is considered the final treatment option for patients with advanced disease. In Vietnam, this procedure has been widely implemented; however, there is still a lack of studies describing the clinical and paraclinical characteristics of these patients. Objective: To describe the clinical and paraclinical characteristics of patients with severe knee osteoarthritis undergoing total knee arthroplasty at Can Tho University of Medicine and Pharmacy Hospital from 11/2023 to 11/2024. Materials and Methods: A descriptive case series was conducted on 10 patients (16 knees) with severe knee osteoarthritis who underwent total knee arthroplasty at the study site between November 2023 and November 2024. Results: Most patients were postmenopausal women aged over 60 years, with common comorbidities such as hypertension and diabetes mellitus. The main clinical presentations included chronic knee pain, joint deformity, and limited mobility. Radiographic findings showed advanced degenerative changes, including joint space narrowing. After surgery, patients demonstrated improvement in pain, increased knee range of motion, and better functional outcomes. Conclusion: Patients undergoing total knee arthroplasty were predominantly elderly women with long-standing symptoms and significant joint deformity. The procedure was associated with improvements in pain and functional status.

Article Details

References

1. World Health Organization. Musculoskeletal conditions. Geneva: WHO. 2022. Retrieved from https://www.who.int/news-room/fact-sheets/detail/musculoskeletal-conditions
2. He, Y.; Li, Z.; Alexander, P.G.; Ocasio-Nieves, B.D.; Yocum, L.; Lin, H.; Tuan, R.S. Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models. Biology 2020. 9, 194. https://doi.org/10.3390/biology9080194
3. Azar FM, Canale ST, Beaty JH, editors. Campbell’s Operative Orthopaedics. 14th ed. Amsterdam: Elsevier Health Sciences. 2021. Chapter: Arthroplasty of the Knee. ISBN: 9780323672177.
4. Lê, V.H. và cộng sự. Đánh giá kết quả sớm phẫu thuật thay khớp gối toàn phần loại không liên kết điều trị thoái hóa khớp gối. Tạp chí Y Dược học Cần Thơ. 2024. 77, 398–404. Doi: https://doi.org/10.58490/ctump.2024i77.2712.
5. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957. 16(4), 494-502.
6. Lực, T.V., Hương, N.T.T., Thướng, V.D., Tâm, N.N. và Huyền, V.T.T. Một số yếu tố liên quan đến đau khớp gối mạn tính ở bệnh nhân cao tuổi có thoái hóa khớp gối nguyên phát. Tạp chí Nghiên cứu Y học. 2023. 165, 4, 25-33. DOI:https://doi.org/10.52852/tcncyh.v165i4.1485.
7. Tuấn, N.V. và Cúc, H.T. Đặc điểm lâm sàng, cận lâm sàng và một số yếu tố nguy cơ đến mức độ nặng ở Bệnh nhân Thoái hóa khớp gối nguyên phát. Tạp chí Y học lâm sàng Bệnh viện Trung Ương Huế. 2025. 73, 97–104. DOI:https://doi.org/10.38103/jcmhch.2021.73.15.
8. Binh BH, Phuong NTT, Hang VTT, Nhan NTT, Hoa NTN, Van Dung H. Personalized dose reduction strategies for biologic disease-modifying antirheumatic drugs for treating axial spondyloarthritis: a clinical and economic evaluation with predictive modeling. BMC Rheumatol. 2025. 9(1), 60. doi:10.1186/s41927-025-00516-9.