TÌNH HÌNH SỬ DỤNG KHÁNG SINH TRONG ĐIỀU TRỊ ĐỢT CẤP BỆNH PHỔI TẮC NGHẼN MẠN TÍNH TẠI BỆNH VIỆN ĐA KHOA TỈNH SÓC TRĂNG NĂM 2024

Abstract

  Background: Chronic Obstructive Pulmonary Disease is one of the three leading causes of death worldwide. Acute exacerbations are critical events in the disease progression, often caused by lower respiratory tract infections. Appropriate antibiotic use is essential to control infections and minimize the risk of drug resistance. Therefore, this study was conducted to evaluate the current status and appropriateness of antibiotic useand to contribute to the optimization of drug management strategies at the facility. Objectives: To evaluate the current status and appropriateness of antibiotic use in treating acute exacerbations of Chronic Obstructive Pulmonary Disease at Soc Trang General Hospital. Materials and methods: A cross-sectional study was conducted on the medical records of patients with acute exacerbations of Chronic Obstructive Pulmonary Disease treated as inpatients from January 1, 2024, to December 31, 2024, who were prescribed antibiotics. Appropriateness was assessed based on Decision Number 2767 of the Ministry of Health. Results: The patients had a mean age of 71.5 years, with males accounting for 89.4%. Hypertension was the most common comorbidity at 46.3%. Moderate exacerbations accounted for 83.3%, and purulent sputum symptoms were recorded in 61.2% of cases. Dual antibiotic therapy predominated at 63.0%; among which levofloxacin, ceftriaxone, and piperacillin + tazobactam were the most frequently used. The median duration of antibiotic use was 5 days. The rate of appropriate antibiotic indication according to the Ministry of Health was 61.2%. Conclusions: The study recorded a 61.2% appropriateness rate for antibiotic indications; however, this rate may not fully represent clinical reality due to its dependence on the level of detail in medical record documentation and specific pathological situations.