NGHIÊN CỨU VỀ MỨC ĐỘ ĐỀ KHÁNG KHÁNG SINH CỦA VI KHUẨN ESCHERICHIA COLI GÂY NHIỄM TRÙNG HUYẾT TẠI KHOA VI SINH BỆNH VIỆN CHỢ RẪY

Abstract

Background: In recent years, the incidence of Escherichia coli infections has been increasing, accompanied by a rise in antibiotic-resistant strains, leading to higher mortality rates. Objectives: To delve into and elucidate the antimicrobial resistance patterns of E. coli isolated from blood cultures. Our goal was to gain a comprehensive understanding of the resistance levels of this bacterium to commonly used antibiotics. Materials and methods: We conducted a cross-sectional descriptive study involving 55 blood samples confirmed to contain E. coli. Each specimen underwent a rigorous process of bacterial identification and antimicrobial susceptibility testing. Specifically, we utilized the automated Vitek 2 Compact system to determine the minimum inhibitory concentrations (MIC), thereby assessing antibiotic resistance. Results: Notably, ampicillin exhibited the highest resistance rate at 92.7% among all tested samples. Ciprofloxacin followed with a resistance rate of 76.4%. Conversely, antibiotics with low resistance rates included cefoperazonesulbactam (1.8%), amikacin (3.6%), and carbapenems (ranging from 0% to 1.8%). Conclusions: E. coli demonstrates significant resistance to several important antibiotic classes. The observed resistance rates for drugs belonging to the beta-lactam, quinolone, and sulfonamide groups ranged from 43.6% to 92.7%. Conversely, the bacterium demonstrated low resistance to carbapenem, amikacin, and cefoperazone-sulbactam antibiotics (ranging from 0% - 3.6%).