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Issue: No. 90 (2025): Kỷ niệm 10 năm thành lập Tạp chí Y Dược học Cần Thơ 2015-2025
Section: Article
DOI: 10.58490/ctump.2025i90.4070
Date Published: 25/08/2025
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Luong, T. M. T., Tran, T. T. T., Nguyen, B. C., Nguyen, V. T., Tran, T. T. H., Nguyen, H. T., Nguyen, P. H. S., & Pham, K. A. T. (2025). PREVALENCE AND RISK FACTORS OF SARCOPENIA IN ELDERLY PATIENTS WITH TYPE 2 DIABETES MELLITUS. Cantho Journal of Medicine and Pharmacy, 90, 178-186. https://doi.org/10.58490/ctump.2025i90.4070

PREVALENCE AND RISK FACTORS OF SARCOPENIA IN ELDERLY PATIENTS WITH TYPE 2 DIABETES MELLITUS

Thi Minh Trang Luong1, Thai Thanh Tam Tran1, , Bich Cham Nguyen1, Van Trinh Nguyen1, Thi Thuy Hang Tran1, Hoang Tin Nguyen1, Phan Hai Sam Nguyen1, Kieu Anh Tho Pham1
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Sarcopenia, a syndrome characterized by the progressive decline in muscle mass and strength, is common in elderly patients with type 2 diabetes mellitus. Objectives: To determine the prevalence of sarcopenia and identify associated factors in elderly patients with type 2 diabetes mellitus. Materials and methods: This cross-sectional study with a control group was conducted at Can Tho University of Medicine and Pharmacy Hospital, comparing patients aged ≥ 60 years with type 2 diabetes mellitus (n =66) to non-diabetic controls (n=71) matched for age and sex. Sarcopenia was diagnosed using the 2019 criteria of the Asian Working Group for Sarcopenia. Multivariate logistic regression was performed to identify independent risk factors. Results: The prevalence of sarcopenia was significantly higher in the type 2 diabetes mellitus group compared to the control group (53.0% vs. 29.6%; p=0.005). In patients with type 2 diabetes mellitus, low body mass index (odds ratio: 1.82; 95% confidence interval: 1.17-2.83; p=0.007) was identified as an independent risk factor. Conclusion: Elderly patients with type 2 diabetes mellitus have a significantly higher risk of sarcopenia compared to non-diabetic individuals. Low body mass index is an independent risk factor for sarcopenia, emphasizing the need for targeted screening and early intervention in this population. 

Keywords

Sarcopenia, type 2 diabetes mellitus, insulin resistance, muscle mass, handgrip strength

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References

1. Saeedi P., Petersohn I., Salpea P., Malanda B., Karuranga S., et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice. 2019, 157, https://doi.org/10.1016/j.diabres.2019.107843.
2. Izzo A., Massimino E., Riccardi G., Della Pepa G. A narrative review on sarcopenia in type 2 diabetes mellitus: Prevalence and associated factors. Nutrients. 2021, 13(1), 183, https://doi.org/10.3390/nu13010183.
3. Chen H., Huang X., Dong M., Wen S., Zhou L., et al. The association between sarcopenia and diabetes: From pathophysiology mechanism to therapeutic strategy. Diabetes Metabolic Syndrome and Obesity. 2023, 16, 1541-1554, https://doi.org/10.2147/DMSO.S37275941.
4. Liu Z.J., Zhu C.F. Causal relationship between insulin resistance and sarcopenia. Diabetology & Metabolic Syndrome. 2023, 15(1), 46. https://doi.org/10.1186/s13098-023-01022-z
5. Liu Z., Guo Y., Zheng C. Type 2 diabetes mellitus related sarcopenia: A type of muscle loss distinct from sarcopenia and disuse muscle atrophy. Frontiers in Endocrinology. 2024, 15, 1375610. https://doi.org/10.3389/fendo.2024.1375610.
6. Ai Y, Xu R, Liu L. The prevalence and risk factors of sarcopenia in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetol Metab Syndr. 2021. 13(1), 93, https://pubmed.ncbi.nlm.nih.gov/34479652/.
7. Sazlina S.G., Lee P.Y., Chan Y.M., A Hamid M.S., Tan N.C. The prevalence and factors associated with sarcopenia among community living elderly with type 2 diabetes mellitus in primary care clinics in Malaysia. PLoS One. 2020, 15(5), https://doi.org/10.1371/journal.pone.0233299.
8. Nguyễn Liên Hạnh, Nguyễn Nguyệt Thu, Nguyễn Thu Thuỷ, Bùi Thị Hương Lan. Tình trạng dinh dưỡng, sarcopenia và nhu cầu chăm sóc dinh dưỡng ở người cao tuổi tại một phường của Hà Nội năm 2023. Tạp chí Dinh dưỡng và Thực phẩm. 2024, 20(6), 54-59, https://doi.org/10.56283/1859-0381/827.
9. Hoàng Khắc Tuấn Anh, Vũ Thị Ngọc Bích, Đoàn Lê Tuấn Anh, Trần Thị Hồng Dịu, Nguyễn Thị Thuỳ Chi. Nguy cơ thiểu cơ (Sarcopenia) và xác định một số yếu tố liên quan tới nguy cơ thiểu cơ ở người cao tuổi tại xã Nga Giáp, huyện Nga Sơn, tỉnh Thanh Hóa năm 2022. 2022, https://www.researchgate.net/publication/382563013
10. Chung S.M., Moon J.S., Chang M.C. Prevalence of sarcopenia and its association with diabetes: A meta-analysis of community-dwelling Asian population. Frontiers in Medicine. 2021, 8, 681232, https://doi.org/10.3389/fmed.2021.681232.
11. Chen L.K., Woo J., Assantachai P., Auyeung T.W., Chou M.Y., et al. Asian Working Group for Sarcopenia: 2019 Consensus update on sarcopenia diagnosis and treatment. Journal of the American Medical Directors Association. 2020, 21(3), 300-307.e2, https://doi.org/10.1016/j.jamda.2019.12.012.
12. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985, 28(7), 412-419, https://doi.org/10.1007/bf00280883.
13. Zhao Y., Li H.F., Wu X., Li G.H., Golden A.R., Cai L. Rural-urban differentials of prevalence and lifestyle determinants of pre-diabetes and diabetes among the elderly in southwest China. BMC Public Health. 2023. 23(1), 603, https://doi.org/10.1186/s12889-023-15527-9.
14. Purnamasari D., Tetrasiwi E.N., Kartiko G.J., Astrella C., Husam K., Laksmi P.W. Sarcopenia and chronic complications of type 2 diabetes mellitus. Review of Diabetic Studies. 2022. 18(3), 157–165, https://doi.org/10.1900/rds.2022.18.157.
15. Mainous A.G., Tanner R.J., Anton S.D., Jo A. Grip strength as a marker of hypertension and diabetes in healthy weight adults. American Journal of Preventive Medicine. 2015. 49(6), 850858, https://doi.org/10.1016/j.amepre.2015.05.025.
16. Brach J.S., Talkowski J.B., Strotmeyer E.S., Newman A.B. Diabetes mellitus and gait dysfunction: Possible explanatory factors. Physical Therapy. 2008. 88(11), 1365-1374, https://doi.org/10.2522/ptj.20080016.
17. Yogesh M., Patel M., Gandhi R., Patel A., Kidecha K.N. Sarcopenia in type 2 diabetes mellitus among Asian populations: Prevalence and risk factors based on AWGS-2019: A systematic review and meta-analysis. BMC Endocrine Disorders. 2025. 25, 101, https://doi.org/10.1186/s12902-025-01935-y.
18. Tam Ngoc Nguyen, Tu Ngoc Nguyen, Anh Trung Nguyen, Thanh Xuan Nguyen, Hoang Thu Thi Nguyen, et al. Prevalence of sarcopenia and its associated factors in patients attending geriatric clinics in Vietnam: a cross-sectional study. BMJ Open. 2020. 10(9). https://bmjopen.bmj.com/content/10/9/e037630.full.