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Date Published: 25/06/2025
Abstract Views: 502
Views PDF: 155
DOI: 10.58490/ctump.2025i88.4006
Issue
No. 88 (2025)
Section
Article
How to Cite
Nguyen, V. L., Nguyen, V. T., Le, V. L., Nguyen, M. Y., Thoi, V. L., Tran, P. T., & Nguyen, N. N. T. (2025). FORMULATION DEVELOPMENT AND DRUG RELEASE EVALUATION OF A TOPICAL GEL-SMEDDS CONTAINING VITAMIN E. Cantho Journal of Medicine and Pharmacy, 88, 304-310. https://doi.org/10.58490/ctump.2025i88.4006

FORMULATION DEVELOPMENT AND DRUG RELEASE EVALUATION OF A TOPICAL GEL-SMEDDS CONTAINING VITAMIN E

Van Liet Nguyen1, , Vinh Tri Nguyen1, Van Lien Le1, Minh Y Nguyen1, Van Loc Thoi1, Phuong Thuy Tran1, Ngoc Nha Thao Nguyen1
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Vitamin E, a potent antioxidant in dermo-cosmetics, faces limited skin penetration in conventional formulations due to its high log P, leading to stratum corneum accumulation and poor bioavailability. Self-Microemulsifying Drug Delivery Systems (SMEDDS), forming nanometer-sized droplets, show promise in enhancing drug permeability. Objective: To improve Vitamin E's transdermal permeability and bioavailability using a SMEDDS gel formulation. Materials and methods: A SMEDDS gel was developed with MCT oil, Tween 80, and Transcutol. Its in vitro membrane permeation was assessed using a Franz Diffusion Cell. Results: The gel-SMEDDS had comparable viscosity to the control, with a particle size of 188.9 nm (PDI = 0.272). It achieved a maximum diffusion of 34.6% after 240 minutes, significantly outperforming the control. Conclusion: The SMEDDS technique successfully produced a novel topical Vitamin E gel with improved bioavailability compared to conventional formulations.

Keywords

SMEDDS, Vitamin E, Topical Gel

Article Details

References

1. Eliza Wargala. Health effects of dyes, minerals, and vitamins used in cosmetics. Women. 2021. 1(4), 223–237, http://doi.org/10.3390/women1040020.
2. Xiaoyuan Wang, Peter J. Quinn. Vitamin E and its function in membranes. Progress in lipid research. 1999. 38(4), 309-336, doi: 10.1016/S0163-7827(99)00008-9.
3. Iw Sayad. Simplistic spectroscopic method for determination of α-Tocopheryl acetate in bulk and formulated microemulsion. Int. J. Pharmaceut. Res. & Allied Sci. 2013. 2, 64–67. https://ijpras.com/storage/models/article/IHP9Jc2n2a95FHHWSHVRZW13pGV3fwYSpuw MOgiJ26GCNASZ6vjyUVgzyHFw/simplistic-spectroscopic-method-for-determination-of-atocopherylacetate-in-bulk-and-formulated-mi.pdf.
4. Shambhu Dokania, Amita K Joshi. Self-microemulsifying drug delivery system (SMEDDS)– challenges and road ahead. Drug delivery. 2015. 22(6), 675–690, doi:
10.3109/10717544.2014.896058.
5. Deepak Kaushik. Recent developments in self-microemulsifying drug delivery system: an overview. Asian Journal of Pharmaceutics (AJP). 2019. 13(02), doi:
10.22377/ajp.v13i02.3101.
6. Ankith Kumar Pandey. Recent developments in self emulsifying drug delivery system. Int J Pharm Sci Rev Res. 2022. 75(2), 145–152, doi: 10.47583/ijpsrr.2022.v75i02.023.
7. Łubkowska B, Hus M, Grobelna B, Maćkiewicz Z. Permeability testing of the vitamins A + E complex contained in emulsions using a Franz diffusion cell. Ukrainian Journal of Dermatology, Venerology, Cosmetology. 2017. 1(64), 25–33, http://www.ujdvc.com.ua/en/arhiv_nomeriv.php?j=3.
8. Simon, Alice, Amaro, Maria Inês, Healy, et al. Comparative evaluation of rivastigmine permeation from a transdermal system in the Franz cell using synthetic membranes and pig ear skin with in vivo-in vitro correlation 2. International journal of pharmaceutics. 2016. 512(1), 234–241, doi:10.1016/j.ijpharm.2016.08.052.
9. Researchgate. Required HLB for Oil/Lipid. 2025. http://www.researchgate.net/Required HLB.pdf.