CHARACTERISTICS OF INDICATORS FOR ASSESSING SARCOPENIA IN ELDERLY PATIENTS WITH TYPE 2 DIABETES
Main Article Content
Abstract
Background: Type 2 diabetes mellitus is a chronic metabolic disease commonly observed in the elderly, contributing significantly to an increased risk of sarcopenia, which adversely affects mobility and quality of life. Parameters such as skeletal muscle index, handgrip strength, and gait speed are known to vary by age and sex. Aging and chronic inflammation associated with type 2 diabetes mellitus can accelerate the decline of these muscle-related indices. Objectives: To describe the characteristics of sarcopenia-related indices in elderly patients with type 2 diabetes mellitus. Materials and methods: A cross-sectional controlled study was conducted on patients aged 60 years and older who attended the Can Tho University of Medicine and Pharmacy Hospital from December 2023 to December 2024. Results: Diabetic patients with low skeletal muscle mass were older (p = 0.022), had lower body weight (p < 0.001), lower body mass index (p < 0.001), and smaller waist circumference (p = 0.038) than those with normal skeletal muscle mass. Male patients showed significantly higher skeletal muscle mass, handgrip strength, and walking speed compared to female patients (p < 0.05). Patients aged 70 years and older exhibited significantly lower walking speed than those under 70 years of age (p = 0.001). Walking speed was also significantly lower among female patients (p =0.040) and among diabetic patients under 70 years of age (p = 0.025) compared to nondiabetic counterparts. Conclusion: Elderly patients with type 2 diabetes mellitus, reductions in skeletal muscle index, handgrip strength, and gait speed are associated with age, sex, and anthropometric characteristics.
Keywords
Sarcopenia, type 2 diabetes, skeletal muscle index, handgrip strength
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References
2. Cruz-Jentoft A.J., Bahat G., Bauer J., Boirie Y., Bruyère O., et al. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing. 2019. 48(1), 16-31, doi:10.1093/ageing/afy169.
3. Zamboni M., Rubele S., Rossi A.P. Sarcopenia and obesity. Current Opinion in Clinical Nutrition and Metabolic Care. 2019. 22(1), 13-19, doi:10.1097/MCO.0000000000000519.
4. ElSayed N.A., Aleppo G., Aroda V.R., Bannuru R.R., Brown F.M., et al. Classification and diagnosis of diabetes: Standards of care in diabetes-2023. Diabetes Care. 2023. 46(1), S19S40, doi:10.2337/dc23-S002.
5. Lin Y.L., Chen S.Y., Lai Y.H., Wang C.H., Kuo C.H., et al. Serum creatinine to cystatin C ratio predicts skeletal muscle mass and strength in patients with non-dialysis chronic kidney disease. Clinical Nutrition. 2020. 39(8), 2435-2441, doi:10.1016/j.clnu.2019.10.027.
6. Chen L.K., Woo J., Assantachai P., Auyeung T.W., Chou M.Y., et al. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. Journal of the American Medical Directors Association. 2020. 21(3), 300-307.e2, doi:10.1016/j.jamda.2019.12.012.
7. Kaur P., Bansal R., Bhargava B., Mishra S., Gill H., Mithal A. Decreased handgrip strength in patients with type 2 diabetes: A cross-sectional study in a tertiary care hospital in north India. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2021. 15(1), 325-329, doi:10.1016/j.dsx.2021.01.007.
8. Mesinovic J., Zengin A., De Courten B., Ebeling P.R., Scott D. Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship. Diabetes, Metabolic Syndrome and Obesity. 2019. 12, 1057-1072, doi:10.2147/DMSO.S186600.
9. Qiao Y.S., Chai Y.H., Gong H.J., Zhuldyz Z., Stehouwer C.D.A., et al. The association between diabetes mellitus and risk of sarcopenia: Accumulated evidences from observational studies. Frontiers in Endocrinology (Lausanne). 2021. 12, 782391, doi:10.3389/fendo.2021.782391.