KẾT QUẢ ĐIỀU TRỊ NHIỄM KHUẨN HUYẾT SƠ SINH NON THÁNG TẠI BỆNH VIỆN NHI ĐỒNG CẦN THƠ NĂM 2023-2024

Abstract

Background: Research on treatment outcomes of neonatal sepsis in preterm infants is of great importance, as this is a severe infectious condition that can rapidly lead to multiple organ failure and death if not promptly managed. Objective: To determine the treatment outcomes of neonatal sepsis in preterm infants. Materials and method: A cross-sectional descriptive study was conducted. Data were collected from 51 preterm neonates (gestational age < 37 weeks) admitted to the Neonatology Department at Can Tho Children's Hospital and diagnosed with neonatal sepsis during a 1-year period from July 2023 to July 2024. Results: Septic shock was observed in 13.7% of cases. Acute kidney injury occurred in 8.0%, and liver injury in 29.1% of cases. All neonates with sepsis were initially treated with combination antibiotic therapy. The most commonly selected firstline regimen was Ampicillin plus Cefotaxime (68.6%). The rate of antibiotic escalation or change was 84.3%. Mechanical ventilation was required in 52.9% of cases, total parenteral nutrition in 58.8%, and vasopressor support in 43.1%. The mortality rate was 11.8%. The average length of hospital stay was 40 ± 25 days. Lower birth weight was associated with a higher rate, and infants requiring mechanical ventilation had a higher mortality rate compared with those not requiring mechanical ventilation; these differences were statistically significant (p < 0.05). Conclusion: This study identified key treatment outcomes of neonatal sepsis in preterm infants, including mortality rate and therapeutic approaches, contributing to a more comprehensive understanding of clinical management in this vulnerable population.