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Issue: No. 90 (2025): Kỷ niệm 10 năm thành lập Tạp chí Y Dược học Cần Thơ 2015-2025
Section: Article
DOI: 10.58490/ctump.2025i90.3932
Date Published: 25/08/2025
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Vo, T. N. A., Nguyen, T. D., Truong, T. T., Pham, T. N. N., Ngo, H. T., Kha, H. N., & Vo, V. D. (2025). ABSTRACT ASSOCIATION BETWEEN RS3746444 POLYMORPHISM OF THE MICRORNA-499 GENE AND THE SEVERITY OF CORONARY ARTERY LESIONS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION. Cantho Journal of Medicine and Pharmacy, 90, 8-14. https://doi.org/10.58490/ctump.2025i90.3932

ABSTRACT ASSOCIATION BETWEEN RS3746444 POLYMORPHISM OF THE MICRORNA-499 GENE AND THE SEVERITY OF CORONARY ARTERY LESIONS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Thi Ngoc Anh Vo1, Thi Diem Nguyen1, , Tu Trach Truong2, Thi Ngoc Nga Pham1, Hoang Toan Ngo1, Huu Nhan Kha1, Viet Duc Vo3
1 Can Tho University of Medicine and Pharmacy
2 Soc Trang Provincial General Hospital
3 Dong Thap Provincial General Hospital

Main Article Content

Abstract

Background: Acute myocardial infarction (AMI) is one of the leading causes of mortality and disability worldwide, particularly in developing countries. In recent years, genetic factors have gained increasing attention in the pathogenesis of acute myocardial infarction. The rs3746444 polymorphism in the microRNA-499 gene has been reported to be associated with cardiovascular disease risk in several populations. However, its correlation with the severity of coronary artery lesions in Vietnamese patients with acute myocardial infarction has not been thoroughly investigated. Objective: To evaluate the association between the rs3746444 polymorphism in the microRNA-499 gene and the severity of coronary artery lesions in patients with acute myocardial infarction. Materials and Methods: A cross-sectional descriptive study was conducted on 81 patients diagnosed with acute myocardial infarction at the Interventional Cardiology Department, Can Tho Central General Hospital. Genotyping of rs3746444 was performed, and coronary lesion severity was assessed via angiography. Results: The AA genotype was present in 79% of patients, AG in 21%, and the GG genotype was not detected. The AG genotype showed a statistically significant association with more severe coronary artery lesions p = 0.035. Conclusion: These findings suggest that the AG genotype may be a genetic factor contributing to the severity of coronary artery damage in acute myocardial infarction patients. 

Keywords

rs3746444 polymorphism, coronary artery lesions, acute myocardial infarction

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References

1. Nader Salari, Fatemeh Morddarvanjoghi, Amir Abdolmaleki, et al. The global prevalence of myocardial infarction: a systematic review and meta-analysis. BMC Cardiovascular Disorders. 2023. 23 (1), 206, DOI: 10.1186/s12872-023-03231-w.
2. Jun-Yu Lu, Meng-Hua Chen, Jian-Feng Zhang, et al. Association between miR-499 rs3746444 polymorphism and coronary heart disease susceptibility: An evidence-based meta-analysis of 5063 cases and 4603 controls. Gene. 2019. 698; 34-40, DOI: 10.1016/j.gene.2019.02.045.
3. W. Ding, M. Li, T. Sun, et al. A polymorphism rs3746444 within the pre-miR-499 alters the maturation of miR-499-5p and its antiapoptotic function. J Cell Mol Med. 2018. 22 (11), 54185428 DOI: 10.1111/jcmm.13813.
4. Kristian Thygesen, S. Alpert Joseph, S. Jaffe Allan, et al. Fourth Universal Definition of Myocardial Infarction. Journal of the American College of Cardiology. 2018. 72 (18), 22312264, https://doi.org/10.1161/CIR.0000000000000617.
5. Trần Công Duy, Lê Gia Hoàng Linh. Association between ACE I/D genetic polymorphism and the severity of coronary artery disease in Vietnamese patients with acute myocardial infarction. 2023. Frontiers in Cardiovascular Medicine, https://doi.org/10.3389/fcvm.2023.1091612.
6. Nguyễn Nhật Tài, Hoàng Văn Sỹ,Trần Nguyễn Phương Hải. Tần suất và đặc điểm của hội chứng chuyển hóa trên bệnh nhân nhồi máu cơ tim cấp. Tạp chí Y học Việt Nam. 2023. 530(2). 219223. https://doi.org/10.51298/vmj.v530i2.6834.
7. Jung‑Hoon Sung, Sang‑Hoon Kim, Woo‑In Yang, et al. miRNA polymorphisms (miR‑146a, miR‑149, miR‑196a2 and miR‑499) are associated with the risk of coronary artery disease. Mol Med Rep. 2016. 14 (3), 2328-2342, DOI: 10.3892/mmr.2016.5495.
8. Ong Văn Phát, Phạm Thanh Phong, Phạm Thị Ngọc Nga. Đặc điểm lâm sàng, cận lâm sàng của bệnh nhân nhồi máu cơ tim cấp tại bệnh viện đa khoa trung ương cần thơ năm 2022 – 2024. Tạp chí Y học Việt Nam. 2024. 539(2). 226-231. https://doi.org/10.51298/vmj.v539i2.9838.
9. Cunrong Chen, Huashan Hong, Lianglong Chen. Association of microRNA Polymorphisms with the Risk of Myocardial Infarction in a Chinese Population. Tohoku J Exp Med. 2022. 233(2), 89-94, DOI: 10.1620/tjem.233.89.
10. Hao Qiu, Zheng Chen, Lu Lv, et al. Associations Between microRNA Polymorphisms and Development of Coronary Artery Disease: A Case–Control Study. DNA and Cell Biology. 2019. 39(1), 25-36, DOI: 10.1089/dna.2019.4963.
11. Khalid Khan, Aakif khan, Zia Ur Rahman, et al. Genetic Polymorphism in miRNA Genes and Their Association with susceptibility of Coronary Heart Disease: An Updated Review. Pathology - Research and Practice. 2024. 264 155675, DOI: 10.1016/j.prp.2024.155675.