NGHIÊN CỨU TÌNH HÌNH, MỘT SỐ YẾU TỐ LIÊN QUAN ĐẾN PHẢN ỨNG CÓ HẠI CỦA THUỐC KHÁNG LAO Ở NGƯỜI BỆNH LAO PHỔI TẠI TỈNH BÌNH THUẬN NĂM 2024-2025

Abstract

Background: Tuberculosis reduces the ability to work, increases the social burden and has a high mortality rate. The surveillance system in the National Tuberculosis Control Program still has many limitations in reporting ADR. Objective: To determine the prevalence of and factors concerning adverse drug reactions in patients treated with anti-tuberculosis drugsin Binh Thuan province in 2024. Materials and methods: A descriptive cross-sectional study was conducted on 436 patients with pulmonary tuberculosis in Binh Thuan province in 2024. Results: The rate of adverse reactions in the study was 45.9%, 61% of which were mild. The rate of adverse reactions was higher in the group with diabetes (OR=2.42, 95% CI: 1.41-4.15, p=0.001), chronic obstructive pulmonary disease (OR=1.98, 95% CI: 1.09-3.60, p=0.023), asthma (OR=5.04, 95% CI: 1.6615.34, p=0.002), obesity (OR=2.63, K95% CI: 1.20-5.93, p=0,007), alcohol use (OR=3.35, 95% CI: 2.26-4.97, p=0.001). Conclusion: The study recorded an adverse drug reaction (ADR) rate of 45.9%, with 61% classified as mild. The increased risk of ADRs among patients with diabetes mellitus (DM), COPD, and bronchial asthma indicates that these are important risk factors requiring close monitoring during tuberculosis treatment. The study also found that alcohol consumption is associated with a higher rate of ADRs to anti-tuberculosis drugs, highlighting the need to advise patients undergoing TB treatment to avoid alcohol.