KHẢO SÁT ĐỘC TÍNH CẤP VÀ ĐỘC TÍNH BÁN TRƯỜNG DIỄN CỦA CAO CHUẨN HÓA LÁ CÂY THÙ LÙ CẠNH (PHYSALIS ANGULATA L., SOLANACEAE)

Abstract

  Background: Physalis angulata L. (PAL) is a popular medicinal herb in Vietnam. Accumulated studies show that extracts from PAL have an effect on blood sugar control. However, in Vietnam, studies on standardized PAL leaf extract and its toxicity evaluation are still limited. Objectives: To evaluate acute toxicity and sub-acute toxicity of standardized PAL leaf extract. Materials and methods: Acute toxicity of standardized PAL leaf extract was conducted according to the fixed-dose method of acute oral toxicity. In sub-acute toxicity test, mice were given standardized PAL leaf extract at doses of 200 mg/kg and 400 mg/kg for 28 days. Results: In the acute toxicity test, after 72 hours of giving mice the standardized PAL leaf extract at a dose of 10,000 mg/Kg, no signs of acute toxicity were observed and no mice died. In the sub-acute toxicity test, the body weight of mice in the experimental groups at the dose of 200 mg/kg and 400 mg/kg on day 28 increased significantly compared to the control group; the hematological and biochemical parameters in the groups had no statistically significant differences. Conclusions: The standardized leaf extract of Physalis angulata L. did not exhibit acute toxicity in mice at the dose of 10,000 mg/kg. Administering doses of 200 mg/kg and 400 mg/kg for 28 days, the standardized PAL leaf extract did not affect the hematopoietic function, liver and kidney function in mice.