Article Sidebar

PDF
Date Published: 17/12/2022
Online Published: 17/01/2023
Abstract Views: 1164
Views PDF: 533
DOI: https://doi.org/10.58490/ctump.2022i54.379
Issue
No. 54 (2022)
Section
Article
How to Cite
Nguyen , T. M. T. (2023). REVIEW THE ROLE OF THE GUT – MICROBIOTA – BRAIN AXIS IN GASTROINTESTINAL DISORDER AND NEUROPSYCHIATRIC: FROM THEORY TO PRACTICE. Cantho Journal of Medicine and Pharmacy, 54, 202-214. https://doi.org/10.58490/ctump.2022i54.379

REVIEW THE ROLE OF THE GUT – MICROBIOTA – BRAIN AXIS IN GASTROINTESTINAL DISORDER AND NEUROPSYCHIATRIC: FROM THEORY TO PRACTICE

Thi Mong Trinh Nguyen 1,
1 Tra Vinh University

Main Article Content

Abstract

The gut – microbiota – brain axis plays a role in the maintenance of homeostasis, systemic regulation, and inflammation of the nervous system in the body. The gut microbiome and the brain communicate through many pathways by two-way signals: brain-gut and gut-brain, influenced by many factors in the body and environment under many connections. On the other hand, the diversity of the gut microbiota tends to decrease with age. Meanwhile, stress and anxiety significantly affect the brain-gut-microbiome axis at all stages of life. Recently, the gut microbiome has emerged as the key player and keyword in the search for the brain-gutmicrobiome axis. Therefore, the influence between the brain and the microbiome is meaningful with the newly born term "gut-microbiota-brain axis". The review provides current information on the influence of the intestinal microbiome on cerebral behavior and gastrointestinal disorders through the gut-brain axis. At the same time, identify potential therapies to treat gastrointestinal disorders and cerebral dysfunction.

Article Details

Keywords

Gut – brain axis, microbion, stress, gastrointestinal disorder

References

1. Appleton J (2018), “The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health”, Integr Med (Encinitas), 17(4), pp.28-32.
2. Aziz MNM, et al. (2021), “Irritable Bowel Syndrome, Depression, and Neurodegeneration: A Bidirectional Communication from Gut to Brain”, Nutrients, 13(9), pp.3061.
3. Bercik P, Verdu EF, Foster JA, et al. (2010), “Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice”, Gastroenterology, 139, pp.2102-2112.
4. Carabotti M, et al. (2015), “The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems”, Ann Gastroenterol, 28(2), pp.203-209.
5. Cenit, Maria Carmen, et al. (2017), “Influence of gut microbiota on neuropsychiatric disorders”, World journal of gastroenterology, 23(30), pp.5486-5498.
6. Chakrabarti, Geurts, Hoyles, L. et al. (2022), The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice, Cellular and Molecular Life Sciences, 79, 80.
7. Chenchen Bi, et al. (2022), “The microbiota–gut–brain axis and its modulation in the therapy of depression: Comparison of efficacy of conventional drugs and traditional Chinese medicine approaches”, Pharmacological Research, 183, 106372.
8. Chong PP, et al. (2019), “The Microbiome and Irritable Bowel Syndrome - A Review on the Pathophysiology, Current Research and Future Therapy”, Front Microbiol, 10(10), pp.1136.
9. Cryan JF, O'Riordan KJ, Cowan CSM, et al. (2019), “The Microbiota-Gut-Brain Axis”, Physiol Rev, 99(4), pp. 1877-2013.
10. Donoso F, Cryan JF, et al. (2022), “Inflammation, Lifestyle Factors, and the Microbiome-GutBrain Axis: Relevance to Depression and Antidepressant Action”, Clin Pharmacol Ther.
11. Kao AC, Harty S, Burnet PW (2016), “The Influence of Prebiotics on Neurobiology and Behavior”, Int Rev Neurobiol, 131, pp.21-48.
12. Maayan Levy, et al. (2017), “Dysbiosis and the immune system”, Nature Reviews Immunology, 17, pp.219-232.
13. Malagelada JR (2020), “The Brain-Gut Team”, Dig Dis, 38(4), pp.293-298.
14. McKernan DP, Fitzgerald P, Dinan TG, et al. (2010), “The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat”, Neurogastroenterol Motil, 22, pp. 1029-1035, e268.
15. Mörkl, S., Butler, Holl, A. et al. (2020), “Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry”, Curr Nutr Rep 9, pp.171-182.
16. Mukhtar, Kashif, et al. (2019), “Functional gastrointestinal disorders and gut-brain axis: What does the future hold?”, World journal of gastroenterology, 25(5), pp.552-566.
17. O'Mahony L, McCarthy J, Kelly P, et al. (2005), “Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles”, Gastroenterology, 128, pp.541-551.
18. Rutsch A, Kantsjö JB, Ronchi F (2020), “The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology”, Front Immunol, 11, pp. 604179.
19. Wang P, Tu K, Cao P, et al. (2021), “Antibiotics-induced intestinal dysbacteriosis caused behavioral alternations and neuronal activation in different brain regions in mice”, Mol Brain, 14(1), pp.49.
20. Zhu, Tu, et al. (2022), “The Microbiota–Gut–Brain Axis in Depression: The Potential Pathophysiological Mechanisms and Microbiota Combined Antidepression Effect”, Nutrients, 14(10), pp.2081.