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STUDY ON CLINICALLY SIGNIFICANT DRUG INTERACTIONS AND RELATED FACTORS IN OUTPATIENT PRESCRIPTION AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL IN 2021
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Abstract
Background: Drug-drug interactions are one of the common problems in clinical practice, which can have serious consequences and adversely affect treatment outcomes for patients. Evaluation of drug interactions based on consensus from many databases will help us be more certain about the possibility of drug interactions, thereby paying more attention to these interactions in clinical practice to ensure the rational use of drugs for the patient. Objectives: 1. Determining the rate and extent of clinically meaningful drug interactions in outpatient prescriptions at Can Tho University of Medicine and Pharmacy Hospital in 2021; 2. Exploring some related factors of drug interactions means clinical in outpatient prescription at Can Tho University of Medicine and Pharmacy Hospital in 2021. Materials and methods: Conducting a cross-sectional descriptive study of 612 outpatient prescriptions at the Department of Medical Examination of Can Tho University of Medicine and Pharmacy Hospital in 2021. Evaluation of drug interactions by 3 drug interaction lookup websites: Drugs.com, Medscape and IBM Micromedex. Results: Prescriptions containing 2-4 drugs have a clinically significant drug interaction rate of 28.4%, prescriptions with 5-7 drugs have a clinically significant drug interaction rate of 69.5% and prescriptions with over 8 drugs have a rate of 91.7%. Prescriptions from patients under 60 years of age have the rate of clinically significant drug interactions occurring 49.8%, prescriptions from patients aged 60 years have a rate of clinically significant drug interactions of 79.2%. There is a relationship between clinically significant drug interactions, the number of drugs used in the prescription and the age of the patient. Conclusions: There is a statistically significant relationship between the number of drugs on the patient's prescription and the age of the patient on the likelihood of a clinically significant drug interaction (p<0.001).
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Keywords
Drug interactions, clinically significance, outpatient prescriptions
References
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