KHẢO SÁT ĐẶC ĐIỂM ĐA HÌNH GEN RS2383207 GEN CDKN2B – AS1 Ở BỆNH NHÂN HỘI CHỨNG ĐỘNG MẠCH VÀNH MẠN TẠI BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ NĂM 2023 – 2025

Abstract

Background: The rs2383207 polymorphism of the CDKN2B-AS1 gene is associated with atherosclerosis, leading to coronary artery narrowing and chronic coronary syndrome (CCS). Objectives: To investigate the characteristics of the rs2383207 polymorphism of the CDKN2B-AS1 gene in patients with chronic coronary syndrome. Materials and methods: A cross-sectional descriptive study was conducted on 44 patients diagnosed with chronic coronary syndrome who were admitted to Can Tho University of Medicine and Pharmacy Hospital from 2023 to 2025. DNA was extracted from patient blood samples and analyzed for genetic polymorphism using the Realtime PCR method. Results: Among 44 CCS patients at Can Tho University of Medicine and Pharmacy Hospital, the frequency and proportion of the rs2383207 polymorphism of the CDKN2BAS1 gene were as follows: GG genotype in 61.4% of cases, GA genotype in 34.1%, and AA genotype in 4.5%. Allele frequencies were 78.4% for the G allele and 19% for the A allele. Cardiovascular risk factors, including hypertension (p = 0.045), diabetes mellitus (p = 0.015), and dyslipidemia (p = 0.004), were significantly associated with the rs2383207 polymorphism. However, other factors such as smoking, obesity, family history of early cardiovascular disease, and physical inactivity showed no significant association. Conclusions: The rs2383207 polymorphism of the CDKN2BAS1 gene in chronic coronary syndrome patients exhibited the following distribution: GG genotype (61.4%), GA genotype (34.1%), and AA genotype (4.5%). Additionally, the rs2383207 polymorphism is associated with hypertension, diabetes mellitus, and dyslipidemia.