STUDY ON THE SHORT-TERM RESULTS OF SHORT DUAL ANTIPLATELET THERAPY IN PATIENTS WITH CHRONIC CORONARY DISEASE WHO RECEIVED POLYMER-FREE DRUG- COATED CORONARY STENTS

Huynh Minh Tri Pham1,, Trung Cang Huynh 2, Son Nam Nguyen 1, Le Uyen Nhi Dinh 1
1 An Giang Center General Hospital
2 Kien Giang General Hospital

Main Article Content

Abstract

Background: Percutaneous coronary intervention (PCI) by catheter is increasingly popular and confirms its absolute role in the treatment of chronic coronary artery disease. Polymer-free drug-coated coronary stents not only minimize the duration of DAPT but also have a high resistance to restenosis during the intervention. Objectives: To evalate the short-term results of short DAPT and identify the associated factors in patients at high bleeding risk. Materials and methods: We performed the prospective and cross-sectional study on 78 patients at high bleeding risk with chronic coronary artery disease at An Giang Center General Hospital. Results: The mean of age of the study subjects was 67.8±12.01. Clinical symptoms after intervention (NYHA, CCS) were clearly improved. Deaths caused by cardiovascular disease had 2 cases (14.4%), and 1 patient had a stroke when shortening the antiplatelet time. Female gender, age ≥75, Hb<10g/dL, BMI ≥23 were associated with adverse events.  Conclusions: In patients at high bleeding risk requiring a shortened duration of DAPT, BioFreedom polymer-free drug-coated stents are safe and effective in chronic coronary intervention.  

Article Details

References

1. Nguyễn Mạnh Quân (2019), Đánh giá hiệu quả trong can thiệp động mạch vành của stent phủ thuốc không polymer, Tạp chí Tim mạch học Việt Nam, 86, tr. 34-39.
2. Nguyễn Mạnh Quân (2021), Đánh giá kết quả can thiệp bằng stent phủ thuốc không Polymer – BioFreedom ở bệnh nhân động mạch vành, Luận án Tiến sĩ Y học, Trường Đại học Y Hà Nội.
3. Grigoris Chatzantonis (2020), Real-world analysis of a Biolimus A9 polymer-free drug-coated stent with very short dual antiplatelet therapy in patients at high bleeding risk, Herz, pp. 1-8.
4. Juhani Knuuti, William Wijins, Antti Saraste et al (2020), 2019 ESC Guidelines for diagnostic and management of chronic coronary syndromes: The Task Force for diagnosis and management of chronic coronary syndromes of the European Society of Cardiology, European Heart Journal, 41(3), pp. 407-477.
5. Philippe Garot (2017), 2-Year Outcomes of High Bleeding Risk Patients After Polymer-Free Drugs-Coated Stents, Journal of the American College of Cardiology, 69(2), pp. 162-171.
6. Philip Urban (2015), Polymer-free Drug-Coated Coronary Stents in Patients at High Bleeding Risk, The New England Journal of Medicine, pp. 1-10.
7. Ron Waksman (2017), Polymer-free Biolimus A9-coated stents in the treatment of de novo coronary lesions with short DAPT: 9-month angiographic and clinical follow-up of the prospective, multicenter BioFreedom USA clinical trial, Cardiovascular Revascularization Medicine, 18(7), pp. 475-481.
8. Roxana Mehran (2021), 3- or 1-Month DAPT in Patients at High Bleeding Risk Undergoing Everolimus-Eluting Stent Implantation, Cardiovascular Interventions, 14(17), pp. 1870-1883.
9. Roxana Mehran, Sunil V. Raoo, Deepak L. Bhatt et al (2011), Standardized Bleeding Definitions for Cardiovascular Clinical Trials, Circulation, 123, pp. 2736-2747.