NGHIÊN CỨU TÌNH HÌNH SỬ DỤNG THUỐC GIẢM ĐAU KHÁNG VIÊM KHÔNG STEROID TRONG ĐIỀU TRỊ MỘT SỐ BỆNH CƠ XƯƠNG KHỚP VÀ ĐÁNH GIÁ TÍNH HỢP LÝ THEO MỨC ĐỘ NGUY CƠ TRÊN TIÊU HOÁ - TIM MẠCH TẠI BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ NĂM 2021

Abstract

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used drug groups in musculoskeletal diseases. However, this group of drugs causes many adverse reactions, especially in the digestive and cardiovascular systems, so it should be given due attention. Objectives: Determining the ratio of using NSAIDs in treating some musculoskeletal diseases, assessing the level of risk and rationality of NSAIDs on gastrointestinal - cardiovascular. Materials and methods: A cross-sectional descriptive study was performed on 386 musculoskeletal patients prescribed to use at least one NSAIDs in general internal medicine and orthopedic clinics at the Can Tho University of Medicine and Pharmacy Hospital from January 2021 to December 2021. Patients were assessed for gastrointestinal-cardiovascular risk and the rationality of using NSAIDs according to the Quebec Medical Council's protocol. Results: The rate of using selective NSAIDs on COX-2 is 93%, of which celecoxib is the most prescribed drug (64.2%). Patients with moderate to high gastrointestinal risk are 63.5%. The rate of patients with low to moderate cardiovascular risk is 71.2%, and high cardiovascular risk is 28.8%. The rate of the reasonable ratio of NSAIDs prescription to gastrointestinal risk is 62.7%, cardiovascular is 73.8%, and appropriate for both gastrointestinal and cardiovascular risk is 55.4%. Conclusion: Using NSAIDs in musculoskeletal patients accounts for a high rate. The use of NSAIDs in the study is relatively consistent. However, more attention should be paid to assessing risk factors for patients before taking the drug.