ANTIBIOTIC RESISTANCE TO CARBAPENEM GROUP AND CARBAPENEMASE-PRODUCING ENZYME IN ENTEROBACTERIACEAE, PSEUDOMONAS AERUGINOSA, AND ACINETOBACTER BAUMANNII AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL IN 2024-2025
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Abstract
Background: Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii are common pathogens that have developed the ability to produce carbapenemase enzymes, reducing the effectiveness of carbapenem antibiotics and creating significant challenges in the treatment of infections. Objectives: 1) To determine the carbapenem antibiotic resistance rate of some bacteria in the Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii; 2) To determine the rate of carbapenemase enzyme production by some bacteria in the Enterobacteriaceae family, Pseudomonas aeruginosa, and Acinetobacter baumannii. Materials and methods: Patients infected with at least one of the bacteria from the Enterobacteriaceae family, Pseudomonas aeruginosa, or Acinetobacter baumannii isolated at Can Tho University of Medicine and Pharmacy Hospital were studied. Bacterial identification was performed using culture methods and an automatic identification system, and carbapenemase production was determined by the modified carbapenem inactivation method (mCIM). Results: Among the 330 bacterial isolates, the average resistance rate to carbapenem antibiotics was 34.6%, with imipenem being the most resistant. Acinetobacter baumannii exhibited the highest resistance rate, followed by Pseudomonas aeruginosa, while Enterobacteriaceae showed the lowest. Of the 184 carbapenem-resistant isolates, 56.0% were capable of producing carbapenemase enzymes, with higher prevalence observed in strains resistant to meropenem and doripenem. The highest carbapenemase production rate was recorded in Acinetobacter baumannii, followed by Pseudomonas aeruginosa and Enterobacteriaceae. Conclusion: Carbapenem resistance is significantly high, particularly in Acinetobacter baumannii, highlighting the need for antimicrobial stewardship, infection control, and continuous surveillance to prevent the spread of resistant bacteria.
Keywords
carbapenem, carbapenemase, Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter baumannii
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References
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