ELECTROENCEPHALOGRAM CHARACTERIZATION IN SUBJECTS WITH POST-COVID SYMPTOMS

Linh Ly Luong1, , Tan Khai Hoan Nguyen1, Thi Tuyet Nhi Le1, Anh Phuc Nguyen1
1 Hong Bang International University

Main Article Content

Abstract

Background: Electroencephalography (EEG) is a technique used to assess central nervous system function by recording neuronal electrical activity in the cortex, aiding in the diagnosis, treatment, and detection of brain disorders. Objective: To characterize brain wave features (amplitude, index, and synchronization) in post-COVID-19 patients. Materials and Methods: A cross-sectional study was conducted on 68 individuals with post-COVID-19 symptoms. Results: Compared to healthy individuals, subjects with post-COVID-19 symptoms exhibited increase beta amplitude and theta-delta index, but decrease alpha and theta-delta amplitudes, as well as alpha and beta indexes. Male subjects with post-COVID-19 syndrome showed higher theta-delta index in both cortical regions, lower alpha amplitude in both regions, temporal beta amplitude, occipital theta-delta amplitude, and temporal alpha index than female subjects. There are no differences in amplitude, index of alpha, beta, theta and delta wave between the two hemispheres from each region in either sexes. Conclusion: COVID-19 can cause significant changes in EEG, different between sexes and compared to healthy individuals.

Article Details

References

1. Đinh Văn Bền, Điện não đồ ứng dụng trong thực hành lâm sàng. Nhà xuất bản Y học Hà Nội, 2002. 33.
2. Kubota T., Gajera P. K., and Kuroda N., Meta-analysis of EEG findings in patients with COVID-19. Epilepsy Behav. Feb 2021, vol. 115, 107682, doi: 10.1016/j.yebeh.2020.107682.
3. Nguyễn Thị Thanh Bình. Nghiên cứu một số đặc điểm điện não đồ ở trẻ em bình thường từ 10– 14 tuổi. Khoa Y, 2007, 25
4. Lê Thu Liên, Bùi Mỹ Hạnh. Ảnh hưởng của điện châm huyệt nội quang (pc6) lên điện não đồ cơ sở. Tạp chí Sinh lý học. 2002. tập. 6, 29-37.
5. Badenoch J. B. et al. Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis. Brain Commun. 2022. vol. 4, no. 1, fcab297 doi:
10.1093/braincomms/fcab297.
6. Lê Thu Liên, Sinh Lý Học Điện não đồ. Nhà xuất bản Y học, Hà Nội, 2007, 460-464.
7. Federico G., Ciccarelli G., Noce G., Cavaliere C., Ilardi C. R., et al. The fear of COVID-19 contagion: an exploratory EEG-fMRI study. Sci Rep. Mar 4 2024. vol. 14, no. 1, 5263, doi: 10.1038/s41598-024-56014-4.
8. Ana Calzada-Reyes P. G.-G., Trinidad Virués-Alba, Lidia Charroó-Ruiz, Laura Perez-Mayo, Maria Luisa Bringas-Vega, et al. EEG Signatures of COVID-19 Survival compared to close contacts and the Cuban EEG normative database. bioRxiv. June 24, 2024. doi: 10.1101/2024.06.21.600102.
9. Kopanska M., Ochojska D., Muchacka R., Dejnowicz-Velitchkov A., Banas-Zabczyk A., et al. Comparison of QEEG Findings before and after Onset of Post-COVID-19 Brain Fog Symptoms. Sensors (Basel). Sep 1 2022. vol. 22, no. 17, 6606, doi: 10.3390/s22176606.
10. Cave A. E. and Barry R. J., Sex differences in resting EEG in healthy young adults. Int J Psychophysiol. Mar 2021. vol. 161, 35-43, doi: 10.1016/j.ijpsycho.2021.01.008.
11. Babiloni C., Gentilini Cacciola E., Tucci F., Vassalini P., and Chilovi A., et al. Resting-state EEG rhythms are abnormal in post COVID-19 patients with brain fog without cognitive and affective disorders. Clin Neurophysiol. May 2024. vol. 161, 159-172, doi: 10.1016/j.clinph.2024.02.034.
12. Kopanska M., Rydzik L., Blajda J., Sarzynska I., and Jachymek K., et al. The Use of Quantitative Electroencephalography (QEEG) to Assess Post-COVID-19 Concentration Disorders in Professional Pilots: An Initial Concept. Brain Sci. Aug 30 2023. vol. 13, no. 9, 1264, doi: 10.3390/brainsci13091264.
13. Silva-Passadouro B., Tamasauskas A., Khoja O., Casson A. J., Delis I., et al. A systematic review of quantitative EEG findings in Fibromyalgia, Chronic Fatigue Syndrome and Long COVID. Clin Neurophysiol. Jul 2024. vol. 163, 209-222, doi: 10.1016/j.clinph.2024.04.019.
14. Isabel M. Sáez-Landete A. G.-D., Beatriz Estrella-León, Alba Díaz-Cid. Chapter 29 - Electroencephalographic features with COVID-19, Linking Neuroscience and Behavior in COVID-19. 2024. 331-341, doi: 10.1016/B978-0-323-95650-5.00007-0.
15. Aldenkamp A. P., Arends J., de la Parra N. M., and Migchelbrink E. J. The cognitive impact of epileptiform EEG discharges and short epileptic seizures: relationship to characteristics of the cognitive tasks. Epilepsy Behav. Feb 2010, vol. 17, no. 2, 205-9, doi:
10.1016/j.yebeh.2009.11.024.