KHẢO SÁT NỒNG ĐỘ HOMOCYSTEIN MÁU VÀ MỘT SỐ YẾU TỐ LIÊN QUAN Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TÍP 2 TẠI BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ

Abstract

 Background: Diabetes mellitus is one of the fastest-growing global health emergencies of the 21st century. Numerous studies have demonstrated homocysteine as an independent risk factor for the early onset of complications in type 2 diabetes patients, especially when elevated Homocysteine levels are linked to vascular complications, including the early development of renal and cardiovascular complications and increased mortality risk. Objectives: To determine of blood Homocysteine levels and the correlation between several related factors in type 2 diabetes patients at Can Tho University of Medicine and Pharmacy Hospital. Materials and methods: A cross-sectional descriptive study was conducted on 135 type 2 diabetes patients at Can Tho University of Medicine and Pharmacy Hospital. Results: The average age of type 2 diabetes patients was 64.01 ± 11.84 years, with females accounting for 64.44%. The duration of type 2 diabetes diagnosis was 10.66 ± 5.28 years. The mean blood homocysteine level was 8.30 ± 2.83 μmol/L, with 5 patients (3.7%) exhibiting elevated homocysteine. Patients with type 2 diabetes mellitus treated with Metformin, with a history of comorbidities such as hypertension and dyslipidemia, have statistically significant factors influencing the increase in blood Homocysteine levels. A statistically significant positive correlation was observed between blood homocysteine levels and the duration of type 2 diabetes diagnosis (r =0.771; p <0.001) and BMI (r =0.567; p <0.05). Conclusion: Some factors influence blood homocysteine levels in type 2 diabetes mellitus patients, including duration since diagnosis, Metformin, body mass index (BMI), and comorbidities such as hypertension and dyslipidemia.