KHẢO SÁT NỒNG ĐỘ CA125 VÀ MỘT SỐ YẾU TỐ TƯƠNG QUAN Ở BỆNH NHÂN SUY TIM MẠN MẤT BÙ CẤP CÓ PHÂN SUẤT TỐNG MÁU THẤT TRÁI GIẢM

Abstract

Background: CA125 is considered a common biomarker, and changes in CA125 are associated with the severity of the disease in the context of acute decompensation and clinical outcomes in heart failure patients. Objectives: Investigation of CA125 levels and some correlated factors in patients with acute decompensated chronic heart failure with reduced left ventricular ejection fraction. Materials and methods: A descriptive, cross-sectional study involving 110 patients diagnosed with acute decompensated chronic heart failure with reduced left ventricular ejection fraction at the Department of Interventional Cardiology – Neurology, Can Tho University of Medicine and Pharmacy Hospital, and the Department of Internal Cardiology, Can Tho Central General Hospital from September 2024 to March 2025. Results: The mean CA125 level was 48.45 (21.1–126.8) U/mL. Elevated plasma CA125 levels were observed in 68 (61.8%) patients. A statistically significant correlation was found between CA125 levels and the duration of heart failure (r=0.461, p<0.001), systolic blood pressure (r=-0.216, p=0.23), white blood cell count (r=-0.312, p<0,001), and the parameter of inferior vena cava (IVC) diameter (r=0,213, p=0,026). A statistically significant association was observed between elevated CA125 levels and the presence of pleural effusion with OR=2.907 (1.125–7.513), p=0.024, and peripheral edema in heart failure patients with OR=5 (1.952–12.806), p<0.001. Conclusions: The mean CA125 concentration was 48.45 U/ml (21.1–126.8), with 61.8% of patients exhibiting elevated CA125 levels. The study revealed that increased CA125 levels were positively correlated with the duration of heart failure, the diameter of the inferior vena cava and strongly associated with symptoms of systemic and pulmonary venous congestion.