Background: Physalis angulata L. is a wild plant that grows on the banks of rice fields, dikes or abandoned places from North to South in Việt Nam. This is a plant that has been used for a long time and has many effects according to folk medicine such as treating colds, sore throats, coughs with phlegm, breast boils, carbuncles, and scrotal pain in men. This plant is also used to treat viral fever, dengue fever, measles, erythema, chickenpox, and hand, foot and mouth disease. Currently, there is no research on the basic standards for the leaves of the Folium Physalis angulata L. Objective: To develop a basicstandards for raw materials of Physalis angulata L. leaves. Materials and methods: The medicinal material used for research is Physalis angulata L. leaves collected from Kien Giang. The standard base of this plant was developed according to the instructions of Vietnam Pharmacopoeia V. Results: Successfully developed a set of basic standards for raw materials of Physalis angulata L. leaves including: Sensory, microanatomy, powder screening, moisture, total ash, acid insoluble ash, heavy metals, aflatoxins, pesticide residues, qualitative by thin layer chromatography (TLC) and quantitative by UV-Vis spectroscopy. Conclusion: The standard base is application in controlling quality standards of Physalis angulata L. leaves, which has the potential to become a medicinal herb in the future.