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Date Published: 25/05/2025
Abstract Views: 279
Views PDF: 141
DOI: 10.58490/ctump.2025i87.3322
Issue
No. 87 (2025)
Section
Article
How to Cite
Nguyen, V. T. T., Nguyen, T. L., Vo, M. P., & Le, Q. T. (2025). CHARLSON COMORBIDITY INDEX AND SOFA SCORE FOR IN-HOSPITAL MORTALITY PREDICTION IN PATIENTS WITH SEPTIC SHOCK. Cantho Journal of Medicine and Pharmacy, 87, 150-156. https://doi.org/10.58490/ctump.2025i87.3322

CHARLSON COMORBIDITY INDEX AND SOFA SCORE FOR IN-HOSPITAL MORTALITY PREDICTION IN PATIENTS WITH SEPTIC SHOCK

Viet Thu Trang Nguyen1, , Thanh Luan Nguyen2, Minh Phuong Vo1, Quang Trung Le1
1 Can Tho University of Medicine and Pharmacy
2 Hoan My Cuu Long Hospital

Main Article Content

Abstract

Background: Septic shock is a global health burden with a high mortality rate, despite numerous therapeutic interventions having been studied and applied in clinical practice. One contributing factor to the high mortality rate in patients with severe infections is the comorbidity. Objective: To evaluate the Charlson Comorbidity Index (CCI) and SOFA score for in-hospital mortality prediction in patients with septic shock. Materials and methods: A cross-sectional descriptive study was conducted on 95 septic shock patients admitted to the Intensive Care Unit, Hoan My Cuu Long Hospital from March 2023 to May 2024. Results: The mortality rate was 26.3%. Risk factors associated with mortality in multivariate analysis were CCI and SOFA scores. CCI predicts in-hospital mortality in septic shock with AUC 0.76 (95%CI 0.66 - 0.86), at the cutoff point of 2.5 with sensitivity 0.64, specificity 0.74, positive predictive value 0.47, and negative predictive value 0.85. Combining CCI and SOFA scores predict in-hospital mortality with AUC 0.835 (95%CI 0.75 - 0.92), at the cutoff point of 10.5 with sensitivity 0.84, specificity 0.70, positive predictive value 0.50, negative predictive value 0.93. Conclusions: The CCI is fairly predictive of in-hospital mortality, combining CCI with SOFA provides better mortality prediction in septic shock.

Keywords

Charlson Comorbidity Index, SOFA score, mortality prediction, septic shock

Article Details

References

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