KHẢO SÁT HOẠT TÍNH KHÁNG KHUẨN CỦA CAO VỎ HỘT VÀ CAO NHÂN HỘT XOÀI (MANGIFERA INDICA L.).

Abstract

  Background: Mango (Mangifera Indica L.) is one of the long-researched medicinal herbs with hypoglycemic, antioxidant, anti-inflammatory effects along with many clinically proven nutritional components. However, mango seeds have received little research attention and there have been no studies on the pharmacological effects of mango seeds grown in Vietnam. Objective: To investigate the antibacterial activity of the kernels and peels of Mango (Mangifera Indica L.). Materials and methods: Determination of antibacterial activity of mango seed extract and kernel on Propionibacterium acnes, Staphylococcus aureus and Escherichia coli bacteria by agar diffusion method and MIC by agar dilution method. Results: At a concentration of 200mg/mL, the extracts of mango seed peel and mango kernel were both antibacterial against Propionibacterium acnes, Staphylococcus aureus bacteria with aseptic ring size of 23.7mm; 15.0mm respectively for mango kernel and 19.6mm; 12.0mm for mango seed peel, especially for E. coli bacteria, mango seed peel is not able to inhibit, but get 17.0mm for mango kernel. The antibacterial ability of mango kernel extract was almost higher than that of mango seed peel extract on 3 types of bacteria tested. The MIC values of both extracts on S. aureus and E. coli were >5mg/mL. However, for P. acnes, mango kernel extract was more sensitive to mango seed peel extract (5 mg/mL), with a MIC value of 1.25mg/mL. Conclusions: Extracts of mango seed peel and kernel are effective against bacteria Staphylococcus Aureus and Propionibacterium Acnes. However, the antibacterial ability on Escherichia coli was only found on mango kernel extract. This study contributes to the experimental basis of the antibacterial effect of the extract of the peel and kernel of the mango seed.