CĂN NGUYÊN VÀ MỨC ĐỘ KHÁNG KHÁNG SINH CỦA CÁC VI KHUẨN GÂY NHIỄM KHUẨN TIẾT NIỆU Ở BỆNH NHÂN ĐIỀU TRỊ NỘI TRÚ TẠI BỆNH VIỆN HỮU NGHỊ ĐA KHOA NGHỆ AN NĂM 2023

Abstract

Background: Urinary tract infections are a common disease and can cause many dangerous complications if not treated thoroughly. The etiology of Urinary tract infection is diverse, with Gramnegative bacteria being the most common and showing a tendency towards antibiotic multi-resistance. Therefore, monitoring the causes of the disease and the status of antibiotic resistance is necessary to be able to develop appropriate and effective antibiotic use strategies. Objective: To determine the etiology and antibiotic resistance of bacteria causing Urinary tract infection in inpatients undergoing treatment at Huu Nghi General Hospital in Nghe An province in 2023. Materials and methods: Urine samples of inpatients treated at Nghe An General Hospital from May 2023 to August 2023, with indications for urine culture and antibiotic susceptibility testing. Study design: Cross-sectional descriptive study. Results: Among the 278 strains of bacteria causing Urinary tract infection, E. coli accounted for the highest proportion (50.4%), followed by Enterococcus spp. (12.9%), P. aeruginosa (10.1%), and K. pneumoniae (8.6%). E. coli was resistant to many antibiotics, with the highest resistance rate to ampicillin (88.6%). More than half of the E. coli strains produced extended-spectrum beta-lactamase (52.1%). P. aeruginosa was resistant to over 40% of all tested antibiotics, with the highest resistance to flouroquinolons (57.1%) and the lowest resistance to piperacillin and piperacillin/tazobactam (42.9%). K. pneumoniae showed the highest resistance to ampicillin (95.8%), followed by ampicillin/sulbactam (79.2%). Enterococcus spp. showed resistance to macrolides and flouroquinolons ranging from 61.1-75.0%, with 8.3% of strains resistant to linezolid and 2.8% resistant to vancomycin. Conclusion: The common bacteria causing Urinary tract infection are E. coli, Enterococcus spp., P. aeruginosa and K. pneumoniae and they were resistant to many commonly used antibiotics to varying degrees.