FACTORS INFLUENCING THE TREATMENT OUTCOMES OF LOWER EXTREMITY DEEP VEIN THROMBOSIS WITH ENDOVASCULAR INTERVENTION

Van Nut Lam1, Manh Hung Nguyen2,, Minh Bao Luan Tran2
1 Cho Ray Hospital
2 University of Medicine and Pharmacy at Ho Chi Minh City

Main Article Content

Abstract

 Background: Lower extremity deep vein thrombosis (DVT) is a serious condition that can lead to complications such as pulmonary embolism (PE), and post-thrombotic syndrome (PTS). Endovascular intervention has proven effective in rapidly resolving thrombi and reducing PTS risk, but the factors influencing treatment outcomes are not well understood. Objectives: To identify factors affecting the treatment outcomes of acute lower extremity DVT using endovascular intervention, particularly the development of post-thrombotic syndrome. Materials and methods: A retrospective study was conducted on 35 patients treated with endovascular intervention at Cho Ray Hospital from January 2017 to December 2022. Outcomes were evaluated based on thrombus resolution and venous patency rates one-month post-intervention. The relationship between risk factors and PTS development was analyzed. Results: Thrombus resolution of grades 2 and 3 was achieved in 94.7% of patients, with 100% venous patency after one month. PTS occurred in 37.1% of cases, mostly mild. Advanced age, comorbidities, and obesity were significantly associated with PTS development (p<0.05). Conclusions: Endovascular intervention is an effective and safe treatment for acute lower extremity DVT. The advanced age, BMI and residual iliac vein stenosis were shown to be associated with the development of post-thrombotic syndrome after intervention. 

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References

1. R. H. White. The epidemiology of venous thromboembolism. Circulation. Jun 17 2003.107(23 Suppl 1),I4-8. doi:10.1161/01.Cir.0000078468.11849.66.
2. K. J. Shah, T. L. Roy. Catheter-Directed Interventions for the Treatment of Lower Extremity Deep Vein Thrombosis. Life (Basel). Nov 27 2022.12(12)doi:10.3390/life12121984.
3. M. W. Mewissen, G. R. Seabrook, M. H. Meissner, J. Cynamon, N. Labropoulos, et al. Catheterdirected thrombolysis for lower extremity deep venous thrombosis: report of a national multicenter registry. Radiology. Apr 1999.211(1),39-49. doi:10.1148/radiology.211.1.r99ap4739.
4. T. Enden, N. E. Kløw, L. Sandvik, C. E. Slagsvold, W. Ghanima, et al. Catheter-directed thrombolysis vs. anticoagulant therapy alone in deep vein thrombosis: results of an open randomized, controlled trial reporting on short-term patency. J Thromb Haemost. Aug 2009.7(8),1268-75. doi:10.1111/j.1538-7836.2009.03464.x.
5. Arany Soosainathan, Hayley M. Moore, Manjit S. Gohel, Alun H. Davies. Scoring systems for the post-thrombotic syndrome. Journal of Vascular Surgery. 2013.57(1),254-261. doi:10.1016/j.jvs.2012.09.011.
6. Lê Phi Long. Nghiên cứu hiệu quả và an toàn của phẫu thuật - thủ thuật nội mạch loại bỏ huyết khối trong điều trị huyết khối tĩnh mạch sâu chi dưới cấp tính. Đại học Y dược TP.HCM. 2022. 163.
7. E. Ozcinar, N. Dikmen, A. Kayan, M. Kandemir, M. C. Saricaoglu. Pharmacomechanical Thrombectomy and Catheter-Directed Thrombolysis, with or without Iliac Vein Stenting, in the Treatment of Acute Iliofemoral Deep Vein Thrombosis. J Cardiovasc Dev Dis. Jul 9 2024.11(7)doi:10.3390/jcdd11070214.
8. P. Notten, A. J. Ten Cate-Hoek, Cwkp Arnoldussen, R. H. W. Strijkers, Aaea de Smet, et al. Ultrasound-accelerated catheter-directed thrombolysis versus anticoagulation for the prevention of post-thrombotic syndrome (CAVA): a single-blind, multicentre, randomised trial. Lancet Haematol. Jan 2020.7(1),e40-e49. doi:10.1016/s2352-3026(19)30209-1.
9. Yi Zheng, Chunli Cao, Gang Chen, Siming Li, Maolin Ye, et al. Analysis of risk factors for postthrombotic syndrome after thrombolysis therapy for acute deep venous thrombosis of lower extremities. International Journal of Cardiology Cardiovascular Risk and Prevention. 2024/09/01/ 2024.22,200319. https://doi.org/10.1016/j.ijcrp.2024.200319.
10. M. Engeseth, T. Enden, P. M. Sandset, H. S. Wik. Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study. Thromb J. 2021.19(1),3. doi:10.1186/s12959-020-00253-8.