ẢNH HƯỞNG CỦA TÁ DƯỢC TẠO GEL ĐẾN CÁC TÍNH CHẤT CỦA GEL NHŨ TƯƠNG RUTIN

Abstract

  Background: Emulgel is a dosage form combining emulsion and gel. Gelling agent effects to properties of emulgel. Therefore, investigating gelling agent is extremely necessary in the process of formulating emulgel. Objectives: To evaluate the influence of gelling agent on the properties of emulgel containing rutin.  Materials and methods: The emulsion was prepared and incorporated in gel base (carbopol 940 and poloxamer 407). The formulations were evaluated for sensory, pH, droplet size and ability to release active ingredients through cellulose acetate 0.45 µm membrane.  Results: The rutin emulsion was light yellow, pH 6.8; the droplet size was about 4.41 µm, the amount of rutin release after 6 hours was 203.82 µg/cm². Emulgel using carrbopol 940 was milky white, pH 6.37 - 6.82, the droplet size was 6 - 9 µm, releasing about 76% of active ingredients compared to emulsion. Emulgel using poloxamer 407 was milky white, pH 5.8 - 6.8; the droplet size was 0.22 - 0.9 µm, amount of active ingredient release was fewer than emulgel using carbopol 940. Conclusions: Thus, gelling agent affected the droplet size and the ability to release the active ingredient of emulgel.