ĐÁNH GIÁ TÁC DỤNG HẠ ĐƯỜNG HUYẾT IN VIVO CỦA CAO CHUẨN HÓA LÁ CÂY THÙ LÙ CẠNH (PHYSALIS ANGULATA L., SOLANACEAE)

Abstract

 Background: Physalis angulata L. (PAL) has long been used in folk medicine to treat many diseases such as colds, coughs, ... Many studies have shown that extracts from Physalis angulata L. can reduce blood glucose level. However, in Vietnam, there has been no study evaluating the hypoglycemic effect of standardized PAL leaf extract. Objectives: To evaluate the blood glucose stabilizing effect on healthy mice and the hypoglycemic effect on alloxan-induced diabetic mice of standardized PAL leaf extract. Materials and methods: Evaluating the blood glucose stabilizing effect of standardized PAL leaf extract on healthy mice after being given standardized PAL leaf extract at doses of 200 mg/kg and 400 mg/kg for 7 days. Evaluating the hypoglycemic effect on the alloxan-induced hyperglycemic mouse model of standardized PAL leaf extract at doses of 200 mg/kg and 400 mg/kg for 28 days. Results: Standardized PAL leaf extract at doses of 200 mg/kg and 400 mg/kg could stabilize blood glucose in healthy mice. On alloxan-induced diabetic mice, standardized PAL leaf extract at doses of 200 mg/kg and 400 mg/kg showed a hypoglycemic effect equivalent to gliclazide at a dose of 10 mg/kg after 28 days of treatment. Conclusions: Standardized PAL leaf extract at doses of 200 mg/kg and 400 mg/kg can stabilize blood glucose on healthy mice and lower blood glucose on alloxan-induced hyperglycemic mice.