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HELICOBACTER PYLORI ERADICATION EFFICACY OF THERAPY BASED ON THE ANTIBIOTIC SUSCEPTIBILITY IN CHILDREN WITH GASTRITIS AND PEPTIC ULCER
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Abstract
Background: Helicobacter pylori therapy for children get low efficiency, and antibiotic resistance is a major cause of treatment failure. Objective: Evaluate the H. pylori eradication efficacy of therapy based on antibiotic susceptibility in pediatric patients with gastritis and peptic ulcer. Materials and methods: The study was done at Can Tho Children's Hospital from January 2021 to June 2022. We performed upper gastrointestinal endoscopy, cultured H. pylori from biopsies of gastric mucosa, determined antibiotic sensitivity of H. pylori by E-test and treated eradication based on antibiotic susceptibility. After at least 4 weeks of eradication therapy, the effectiveness of treatment was assessed by the urea breath test. Results: Among 50 children recruited in this study, ratio boy/girl were 1/1, the mean age was 10.4±2.3 years. There were 86% of H. pylori resistant to AMO, followed by the figure for CLA, MET, LEV, and TET, valuing 82%, 76%, 60%, and 16% respectively. The eradication rate of H. pylori was 84.8% to PP and 78% to ITT. Conclusions: The proportions of resistance to CLA, AMO, MET, and LEV were high, in contrast to TET, which was lower in pediatrics. Tailored eradication therapy was highly successful in our study. We recommend that in countries with a high prevalence of antibiotic resistance H. pylori strains, eradication therapy base on antibiotic susceptibility should be used as first-line therapy.
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Keywords
Eradication therapy, Helicobacter pylori, children
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