RELATIONSHIP SURVEY AND EVALUATION OF THE RESULTS OF TESTOSTERONE REPLACEMENT IN MALE HYPOGONADISM AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL IN 2023-2024
Main Article Content
Abstract
Background: Male hypogonadism is a health problem that affects many men. Early diagnosis and treatment can improve the quality of life for patients. Testosterone replacement therapy, particularly 1% testosterone gel, is an effective and well-tolerated treatment. Objectives: To investigate of the relationship between male hypogonadism and treatment outcomes with testosterone replacement therapy. Materials and methods: Cross-sectional, prospective study on 34 male hypogonadal patients prescribed testosterone replacement therapy at Can Tho University of Medicine and Pharmacy Hospital from December 2023 to June 2024. Follow-up was conducted for 3 months of treatment. Results: Testosterone levels were associated with the following factors: body mass index, diabetes, waist circumference, dyslipidemia, and varicocele (p < 0.05). 100% of patients had increased blood testosterone levels after 3 months of treatment, and symptoms of hypogonadism improved after treatment with androgen deficiency of the aging male and International Index of Erectile Function. 5.88% reported side effects when using testosterone gel. Conclusion: testosterone replacement therapy is considered the standard therapy for male hypogonadism, in which testosterone gel 1% is a simple and well-tolerated treatment.
Article Details
Keywords
male hypogonadism, testosterone replacement therapy (TRT), androgen deficiency of the aging male (ADAM), International Index of Erectile Function (IIEF)
References
2. Mulhall JP, Trost LW, Brannigan RE, Kurtz EG, Redmon JB, et al. Evaluation and Management of Testosterone Deficiency: AUA Guideline. J Urol. 2018. 200(2), 423-432. doi: 10.1016/j.juro.2018.03.115.
3. Snyder PJ, Bhasin S, Cunningham GR, Matsumoto AM, Stephens-Shields AJ, et al. Testosterone Trials Investigators. Effects of Testosterone Treatment in Older Men. N Engl J Med. 2016. 374(7), 611-24. doi: 10.1056/NEJMoa1506119.
4. Chen W, Liu ZY, Wang LH, Zeng QS, Wang HQ. Are the Aging Male's Symptoms (AMS) scale and the Androgen Deficiency in the Aging Male (ADAM) questionnaire suitable for the screening of late-onset hypogonadism in aging Chinese men?. Aging Male. 2013. 16(3):92-6. doi: 10.3109/13685538.2013.805319
5. Lisco G, Bartolomeo N, Ramunni MI, De Tullio A, Carbone MD, et al. Erectile Dysfunction in Patients with Multiple Chronic Conditions: A Cross- Sectional Study. Endocr Metab Immune Disord Drug Targets. 2023. 23(3), 396-404. doi: 10.2174/1871530322666220523130212
6. Panach-Navarrete J, Morales-Giraldo A, Ferrandis-Cortés C, García-Morata F, Pastor-Lence JC. Is there a relationship between varicocele and testosterone levels? Aging Male. 2020. 23(5), 592598. doi: 10.1080/13685538.2018.1550745.
7. Nguyễn Hoài Bắc, Đinh Hữu Việt, Trần Văn Kiên. Mối liên quan giữa suy giảm testosterone với BMI và rối loạn mỡ máu ở nam giới. Tạp Chí Nghiên cứu Y học. 2023. 168(7), 106-114. doi: 10.52852/tcncyh.v168i7.1744.
8. Nguyễn Hòa Khánh. Nghiên cứu tỉ lệ bệnh danh y học cổ truyền trên bệnh nhân nam suy sinh dục khởi phát muộn (LOH) tại bệnh viện Đa khoa Khu vực Long Thành, tỉnh Đồng Nai. Đại học Y Dược Thành phố Hồ Chí Minh. 2016. 126.
9. Liu YJ, Shen XB, Yu N, Shang XJ, Gu YQ, et al. Prevalence of late-onset hypogonadism among middle-aged and elderly males in China: results from a national survey. Asian J Androl. 2021. 23(2), 170-177. doi: 10.4103/aja.aja_59_20.
10. I. Thanaboonyawat, P. Chera-aree, S. Petyim, R. Choavaratana, P. Laokirkkiat. The effect of three-month topical testosterone gel application on semen quality in men with oligozoospermia and low serum testosterone levels. Clinical and Experimental Obstetric & Gynecol. 2020. 47(6), 875–881. doi: 10.31083/j.ceog.2020.06.5454.
11. Ramasamy R, Scovell JM, Kovac JR, Lipshultz LI. Testosterone supplementation versus clomiphene citrate for hypogonadism: an age matched comparison of satisfaction and efficacy. J Urol. 2014.192(3):875-9. doi: 10.1016/j.juro.2014.03.089.
12. Nguyễn Trung Hiếu, Lê Thanh Bình, Nguyễn Văn Nghĩa, Trần Quốc Cường. Kết quả điều trị bằng testosterone thay thế trên bệnh nhân suy sinh dục nam tại Bệnh viện Trường Đại học Y Dược Cần Thơ. 2023. Tạp chí Y Dược học Cần Thơ, (67), 35-41. doi: 10.58490/ctump.2023i67.2178.