NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG, TÌNH HÌNH BIẾN THỂ GEN AGTR1 A1166C Ở BỆNH NHÂN NHỒI MÁU CƠ TIM CẤP TẠI BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ NĂM 2022-2023

Abstract

Background: Acute myocardial infarction is one of the leading causes of mortality worldwide, although prognosis has improved significantly over the past decade. Research on the AGTR1 A1166C gene variant provides useful information for individualizing and optimizing treatment and prevention of acute myocardial infarction in today's medical era. Objectives: To evaluate the clinical and subclinical characteristics, situation and prognostic value of fatal events of AGTR1 A1166C gene variant in patients with acute myocardial infarction. Materials and methods: A cross-sectional descriptive study was conducted on 70 patients with acute myocardial infarction. Results: The mean age was 65.8 ± 11.2 years old. The male/female ratio was 1.5/1. Patients hospitalized for chest pain accounted for 81.4%. Patients who went to the hospital before 12 hours were 57.1% and 7.2% of patients had Killip IV. Left ventricular systolic function decreased below 40% was 11.2%. The AA genotype accounted for the highest proportion (84.3%), the AC genotype accounted for 15.7% and no patients with the CC genotype were found. The mean age was 63.9 ± 11.6 years with a male/female ratio of 1.5/1. Patients hospitalized for typical chest pain accounted for 81.4%. Most patients had Killip I. Decreased left ventricular systolic function was 10%. Conclusions: There were similarities in clinical and paraclinical characteristics in the two groups of patients with the AA genotype and the AC genotype. AGTR1 A1166C gene variant is associated with hypertension in patients with ST-elevation myocardial infarction.