KẾT QUẢ ĐIỀU TRỊ UNG THƯ BIỂU MÔ TUYẾN TIỀN LIỆT NGUY CƠ CAO ĐẾN RẤT CAO BẰNG PHƯƠNG PHÁP XẠ TRỊ NGOÀI KẾT HỢP VỚI ỨC CHẾ ANDROGEN TẠI BỆNH VIỆN UNG BƯỚU THÀNH PHỐ CẦN THƠ

Abstract

Background: Radiation therapy is an effective treatment method equivalent to prostatectomy for locally staged prostate cancer. Radiotherapy combined with androgen deprivation therapy has been shown to improve survival in patients with high to very-high-risk factors. Objectives: To determine clinical, paraclinical characteristics, and treatment results of high to very high-risk prostate cancer using external radiotherapy combined with androgen deprivation therapy. Materials and method: A case series report of 31 patients with high to very high-risk prostate cancer. They underwent radiotherapy combined with androgen deprivation therapy at Can Tho City Oncology Hospital from March 2022 to March 2024. All the data was analyzed by SPSS 20.0.  Results: The average age of the study group was 69.3 ± 7.2 years old. The most common clinical symptom is urinary hesitancy, with a rate of 64.5%. 80.6% of patients had PSA index > 20 ng/ml. 58.1% of patients had GLEASON score ≥ 8. The number of patients at very high risk was 80.6%. The average radiation dose to the prostate was 72.0 ± 1.0 Gy. Androgen inhibitors were used in 80.6% of cases. The most common complication is grade 1 cystitis, accounting for 61.3%. 54.8% of patients had grade 1 dermatitis complications due to radiation. Conclusion: Radiotherapy combined with androgen deprivation therapy is an effective treatment in patients with high to very high-risk prostate cancer. Treatment toxicity is mainly mild and moderate.