RESEARCH ON STRUCTURAL FEATURES AND TREATMENT RESULTS OF DRY EYE SYNDROME AFTER PHACOEMULSIFICATION SURGERY USING DIQUAFOSOL 3% AND HYALURONATE 0.1% AT CAN THO CITY GENERAL HOSPITAL IN 2023-2024

Lam Phuong Dinh1,, Minh Ly Le2
1 Nam Can Tho University Medical Center
2 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Dry eye syndrome is a common condition following cataract surgery, with various influencing factors and manifestations. Objective: To determine the prevalence, morphological characteristics, and treatment outcomes of dry eye after cataract surgery. Materials and methods: A cross-sectional descriptive study of 479 eyes after cataract surgery at Can Tho City General Hospital from August 2023 to December 2023. Results: 150 out of 479 eyes (31.31%) developed dry eye with the following morphological forms: Area (23.33%), Spot (22%), Line (34%), Dimple (7.33%), and Random (13.33%). The severity of dry eye increased on the first day postsurgery and continued for the next two weeks. Risk factors associated with dry eye included age (mean 65.88±8.9 years; 119/150 cases >60 years), female gender (83/67), cataract density (grades 3,4; 80%), and certain surgery-related factors. The OSDI (Ocular Surface Disease Index) increased on the first day post-surgery, with a mean of 68.16±10.01, compared to pre-surgery at 42.19±10.92. The tear breakup time (TBUT) decreased post-surgery, with a mean of 2.89±2.72 seconds. Initial treatment results showed that the group using Diquafosol 3% achieved an efficacy rate of 98.53%, while the group using Hyaluronate 0.1% had a 97.56% efficacy rate, with TBUT and OSDI indices trending toward normal in the following weeks.Conclusion: Dry eye syndrome is prevalent after cataract surgery, affecting approximately one-third of patients, with all five forms of tear breakup represented, and the line form being the most common. Treatment was effective in 98% of cases, with the remaining 2% showing limited symptom improvement or non-compliance with treatment.

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References

1. Sheppard J., Shen Lee B., and Periman L.M., Dry eye disease: identification and therapeutic strategies for primary care clinicians and clinical specialists. Ann Med. 2023. 55(1), 241-252. doi: 10.1080/07853890.2022.2157477.
2. Craig J.P., et al., TFOS DEWS II Report Executive Summary. Ocul Surf. 2017. 15(4), 802-812, doi: 10.1016/j.jtos.2017.08.003.
3. Naderi K., Gormley J., and O'Brart D., Cataract surgery and dry eye disease: A review. Eur J Ophthalmol. 2020. 30(5), 840-855. doi: 10.1177/1120672120929958.
4. Ishrat S., Nema N., and Chandravanshi S.C.L., Incidence and pattern of dry eye after cataract surgery. Saudi J Ophthalmol. 2019. 33(1), 34-40, doi: 10.1016/j.sjopt.2018.10.009.
5. Wolffsohn J.S., et al., TFOS DEWS II diagnostic methodology report. The ocular surface. 2017. 15(3), 539-574, https://doi.org/10.1016/j.jtos.2017.05.001.
6. Yao K., et al., Efficacy of 1% carboxymethylcellulose sodium for treating dry eye after phacoemulsification: results from a multicenter, open-label, randomized, controlled study. BMC ophthalmology. 2015. 15, 1-10, https://doi.org/10.1186/s12886-015-0005-3.
7. Wang L. and Deng Y., The applications of androgen in the treatment of dry eye disease: a systematic review of clinical studies. Endocrine journal. 2020. 67(9), 893-902. https://doi.org/10.1507/endocrj.EJ20-0178.
8. Ooi K.G.-J., et al., Cataract Surgery and Dry Eye. 2023. https://doi.org/10.1177/11206721209299.
9. Huỳnh Phúc Hoàng và cộng sự, Khảo Sát Sự Thay Đổi Độ Thẩm Thấu Nước Mắt Ở Bệnh Nhân Sau Phẫu Thuật Phaco. Tạp chí Y học Việt Nam. 2024. 535(1B). https://doi.org/10.51298/vmj.v535i1B.8423.
10. Miyake K. and Yokoi N., Influence on ocular surface after cataract surgery and effect of topical diquafosol on postoperative dry eye: a multicenter prospective randomized study. Clinical Ophthalmology, 2017. 529-540,https://doi.org/10.2147/OPTH.S129178.
11. Yokoi N. and Georgiev G.A., Tear Film-Oriented Diagnosis and Tear Film-Oriented Therapy for Dry Eye Based on Tear Film Dynamics. Invest Ophthalmol Vis Sci. 2018. 59(14), DES13-DES22. 10.1167/iovs.17-23700.
12. Cetinkaya S., et al., The course of dry eye after phacoemulsification surgery. BMC ophthalmology. 2015. 15, 1-5.