ĐÁNH GIÁ MỐI TƯƠNG QUAN VÀ ĐỘ TƯƠNG HỢP CỦA GIÁ TRỊ LDL-CHOLESTEROL ĐỊNH LƯỢNG TRỰC TIẾP VÀ ƯỚC TÍNH THEO MỘT SỐ CÔNG THỨC MỚI

Abstract

Background: Estimating low-density lipoprotein cholesterol (LDL-C) concentration using widely accepted formulas has become a feasible alternative in areas with limited access to direct quantitative methods. In addition to the classical Friedewald formula, several new formulas such as Cordova, Martin, and Sampson have been proposed. Most formulas yield acceptable results in various studies. While these formulas are feasible in practice, they require evaluation in the target population before application. Objectives:This study aimed to evaluate the correlation and concordance between directly measured LDL-C levels and estimates derived from the Friedewald, Cordova, Martin, and Sampson formulas. Materials and methods: Data were collected from 1267 patients who underwent full lipid profile testing (including total cholesterol, triglycerides, HDL-C, and LDL-C) at the Laboratory Department of Can Tho City General Hospital (May 2023-November 2023). Results: The Cordova, Martin, and Sampson formulas had a strong correlation at all triglyceride levels in the study, but the Fridewald formula only achieved a strong correlation in the group with concentrations ≤ 3.39 mmol/L. In terms of compatibility level in group I (triglyceride ≤ 2.26 mmol/L), the Friedewald and Cordova formulas had the best compatibility levels; the Friedewald formula showed the best compatibility level in group II (3.39 ≥ triglyceride > 2.26 mmol/L), while the Sampson formula showed the best compatibility level in group III (4.45 ≥ triglycerides > 3.39 mmol/L), and the Martin formula had the best compatibility level in group IV (triglycerides > 4.45 mmol/L). Conclusions: The Friedewald formula and Cordova formula give good results in the low triglyceride group (≤ 3.39 mmol/L); the Martin and Sampson formulas give better results than the other two formulas in the higher triglyceride group and are less affected by triglyceride concentration.

Keywords: LDL-Cholesterol estimation, Friedewald formula, Cordova formula, Martin formula, Sampson formula.