Article Sidebar

PDF
Date Published: 25/08/2024
Online Published: 25/08/2024
Abstract Views: 32
Views PDF: 9
DOI: https://doi.org/10.58490/ctump.2024i79.2764
Issue
No. 79 (2024)
Section
Article
How to Cite
Vo, V. T., Phan, M. N., Thai, H. N. T., Nguyen, H. A. M., Nguyen, T. D., & Le, Q. H. (2024). THE INFLUENCE OF HYPOALBUMINEMIA ON TREATMENT RESULTS AND THE PROGNOSTIC VALUE OF ALBUMIN ON MORTALITY IN PEDIATRIC PATIENTS TREATED AT THE INTENSIVE CARE UNIT, CAN THO CHILDREN’S HOSPITAL IN 2022-2023. Cantho Journal of Medicine and Pharmacy, 79, 149-156. https://doi.org/10.58490/ctump.2024i79.2764

THE INFLUENCE OF HYPOALBUMINEMIA ON TREATMENT RESULTS AND THE PROGNOSTIC VALUE OF ALBUMIN ON MORTALITY IN PEDIATRIC PATIENTS TREATED AT THE INTENSIVE CARE UNIT, CAN THO CHILDREN'S HOSPITAL IN 2022-2023

Van Thi Vo1,, Minh Nhut Phan1, Huynh Ngoc Tran Thai1, Huynh Ai My Nguyen1, Thuy Duy Nguyen1, Quoc Huy Le1
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Albumin is a plasma protein that plays many roles in the body. Albumin is used to assess disease severity, especially in critically ill patients. Hypoalbuminemia is a common homeostatic disorder in critically ill patients. Hypoaluminemia increases mortality, increases the need for mechanical ventilation, and increases the hospital stay. Objectives: To determine the impact of hypoalbuminemia on treatment outcomes and find out the mortality prognostic value of albumin in pediatric patients treated at the Intensive Care Unit of Can Tho Children's Hospital. Materials and methods: A cross-sectional descriptive study was conducted on 80 pediatric patients from 2 months to 15 years old treated at the Intensive Care Unit of Can Tho Children's Hospital from December 2022 to December 2023. Results: The rate of hypoalbuminemia was 57.5%. The group of children with hypoalbuminemia had a higher rate of mechanical ventilation and use of vasopressors than the group of children without hypoalbuminemia (52.2% versus 29.4% and 58.7% versus 32.4%),  is statistically significant at p<0.05. The group of children with hypoalbuminemia had a higher rate of Intensive Care Unit stay >7 days and a higher mortality rate than the group of children without hypoalbuminemia (65.2% vs 8.8% and 67.4% vs 23, 5%). This difference is statistically significant with p < 0.001. With AUC=0.725, albumin value has an average prognostic level. The sensitivity, specificity, positive predictive value and negative predictive value of albumin cutoff=3.395 g/dL were 56.1%, respectively; 89.7%; 85.1% and 66%. Conclusion: The group of children with hypoalbuminemia had a need for mechanical ventilation, the use of vasopressors, the rate of stay in the Intensive Care Unit >7 days and the mortality rate was higher than the group of children without hypoalbuminemia. Albumin has the ability to predict moderate mortality in pediatric patients treated at ICU department with a cutoff point at 3,395g/dL.

Article Details

Keywords

Influence of hypoalbuminemia, mortality prognosis, intensive care unit, children

References

1. Ward E. S., Gelinas D., Dreesen E., Van S. J., Andersen J. T., et al. Clinical Significance of Serum Albumin and Implications of FcRn Inhibitor Treatment in IgG-Mediated Autoimmune Disorders. Frontiers in immunology. 2022. 892534, doi:10.3389/fimmu.2022.892534.
2. Takrani K. G., Kumbhar S. G. Study of hypoalbuminemia in paediatric intensive care unit admitted children. Int J Contemp Pediatr. 2022. 9(4), 371-375, https://doi.org/10.18203/2349-3291.ijcp20220764.
3. Bekhit O. E., Yousef R. M., Abdelrasol H. A., Mohammed M. A. Serum Albumin Level as a Predictor of Outcome in Patients Admitted to Pediatric Intensive Care Units. Pediatr Emerg Care. 2021. 37(12), 855-860, doi:10.1097/PEC.0000000000002567.
4. El-shamy A. Y., Khattab A. A., Adbel-Aziz A. A. Hypoalbuminemia as a predictor of adverse outcome in critically ill children: a prospective cohort study. Menoufia Medical Journal. 2021. 34(4), 1381, https://doi.org/10.21203/rs.3.rs-430440/v1.
5. Trần Thị Như Ý, Lý Quốc Trung, Nguyễn Hồng Ngân, Hà Thị Thảo Mai, Trần Đỗ Hùng. Đánh giá sự giảm albumin máu trên bệnh viêm phổi ở trẻ em từ 2 tháng đến dưới 5 tuổi tại bệnh viện sản-nhi Cà Mau năm 2022-2023. Tạp Chí Y học Việt Nam. 2023. 529(1B), doi:10.51298/vmj.v529i1B.6393.
6. Tiwari L.K., Singhi S., Jayashree M., Baranwal A. K., Bansal A. Hypoalbuminemia in critically sick children. Indian J Crit Care Med. 2014. 18(9), 565-569, doi: 10.4103/0972-5229.140143.
7. Azza A. M., Aminah S., Al H., Mohamed F. Rafa. Evaluation of Hypoalbuminemia as a Predictor of Clinical Outcome in Critically Ill Children in Alexandria University Children's Hospital. J Med Sci Clin Res. 2018. 06(01), 32299-32306, doi:10.18535/jmscr/v6i1.139.
8. Steere E. L., Eubank T. A., Cooper M. H., Greenlee S. B., Drake T. C. Impact of Hypoalbuminemia on Ceftriaxone Treatment Failure in Patients With Enterobacterales Bacteremia: A Propensity-Matched, Retrospective Cohort Study. Open Forum Infect Dis. 2023.
10(3), ofad102, doi:10.1093/ofid/ofad102.
9. Lorenzo L., Andrea C., Nicole O., Nicola C., Paolo P. Hypoalbuminemia and clinical adverse events in children with COVID 19. J Med Virol. 2021. 9(3), 2611–2613. doi: 10.1002/jmv.26856.
10. Gema N. Y., Munar L., Muhammad A. The Influence of Albumin Level in Critically Ill Children to Length of Stay and Mortality in Paediatric Intensive Care Unit. Macedonian Journal of Medical Sciences. 2019. 7(20), 3455-3458, https://doi.org/10.3889/oamjms.2019.445.