SOME CHARACTERS OF ASTHMA IN CHILDREN FROM 6 MONTH TO 5 YEARS WITH INADEQUATE VITAMIN D LEVELS

Huynh Ai Uyen Nguyen1, Minh Phuong Nguyen1,, Quang Nghia Bui1, Thi Thanh Nhan Nguyen1, Cong Ly Tran1, Pham Minh Thu Vo1
1 Can Tho University of Medicine and Pharmacy

Main Article Content

Abstract

Background: Asthma in children 6 months to 5 years of age can be related to a number of factors, particularly vitamin D levels. Objectives: Determine the rate of incomplete vitamin D. Investigate some related factors and some clinical and subclinical characteristics, treatment results in asthmatic children aged from 6 months to 5 years with inadequate vitamin D levels. Materials and methods: A cross-sectional approach with analysis of 30 asthma cases from 6 months to 5 years old at the Department of Respiratory Medicine, Can Tho Children's Hospital, from April 1, 2021 to March 1, 2022. Patients classified the severity of the acute asthma attack, were interviewed with available questionnaires, performed blood counts, measured vitamin D level and followed treatments. Results: The average vitamin D concentration in asthma children from 6 months to 5 years was 34.6±11.3ng/ml. The percentage of children with bronchial asthma with inadequate vitamin D was 33.3%. Several factors were associated with inadequate vitamin D levels: children were not exposed to sunlight for 15-30 minutes a day (75.0%), did not take 400UI vitamin D supplements/day (47.4%). In the group of children with bronchial asthma with inadequate vitamin concentrations, the rate of moderate acute attacks accounted for 90.0%, severe attacks accounted for 10.0%, and the rate of relapse in asthmatic children with inadequate vitamin levels (90.0%) higher than in the group with adequate vitamin concentrations (50.0%) with odds ratio of 9.0 (p=0.032). Vitamin D levels and length of hospital stay were negatively correlated (p=0.386). Conclusions: Children with bronchial asthma have inadequate vitamin D levels (33.3%). The rate of moderate-severe exacerbations and relapse rate in children with inadequate vitamin D levels was higher than in the control group.

Article Details

References

1. Nguyễn Năng An, Lê Văn Khang, Phan Quang Đoàn (2003), “Tình hình dị ứng thuốc ở nước ta. Đề xuất những biện pháp can thiệp”, Đề tài độc lập cấp Nhà nước, Hà Nội, tr.31-45.
2. Trần Quý (2017), “Khảo sát nồng độ vitamin D trong bệnh hen phế quản, viêm da cơ địa ở trẻ em dưới 5 tuổi và tìm hiểu mối liên quan giữa nồng độ vitamin D với các mức độ của bệnh”, Luận văn Thạc sĩ Y học, Đại Học Y Hà Nội.
3. Nguyễn Lương Tâm (2017), “Hiệu quả sử dụng vitamin D trong dự phòng hội chứng nhiễm khuẩn hô hấp cấp do vi rút ở người khỏe mạnh tại cộng đồng huyện Thanh Liêm, tỉnh Hà Nam”, Luận án Tiến sĩ Y tế công cộng, Đại học Y Hà Nội.
4. Nguyễn Đức Trí (2020), “Nghiên cứu tình trạng thiếu vitamin D ở trẻ viêm phổi từ 2 tháng đến 5 tuổi tại Bệnh viện Nhi đồng thành phố Cần Thơ”, Luận văn Chuyên khoa cấp II, Đại học Y Dược Cần Thơ
5. Bener A, Ehlayel MS, Tulic MK, et al. (2012), “Vitamin D deficiency as a strong predictor of asthma in children”, Int Arch Allergy Immunol, 157(2), pp.168-175.
6. Le Quynh Chi, Lu Thi Hanh, Le Thi Hong Hanh (2020), “Correlation between Certain Viruses and Severity of Acute Asthma in Children”, Journal of Pediatric Research and Practice, 4(6), pp.61-67.
7. Dusso A.S, Brown A.J, Slatopolsky. E (2005), Vitamin D, Am J Physiol Renal Physiol, 289, pp.8-28.
8. Gupta A, Sjoukes A, Richards D, et al. (2011), “Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma”, Am J Respir Crit Care Med, 184, pp.1342-1349.
9. Kumar. P, Gowdra. A, Arathi. A, et al. (2007), “A clinical study to determine the relationship between serum vitamin D levels and severity of asthma”, International Journal of Contemporary Pediatrics, Vol 4, Issue 4, pp. 1397.
10. Mahmut.D, Heves.K, Rahime.G.Y.M, and et al. (2014), “Clinical Effects of Vitamin D in Children with Asthma”, International archives of Allergy and Immunology, 164, pp.319-325.
11. Martineau AR, Cates CJ, Urashima M, et al. (2016), “Vitamin D for the management of asthma”, Cochrane Database Syst Rev, 9, pp.17-19.
12. Phuong Minh Nguyen, Linh Van Pham, Kien Trung Nguyen, et al. (2020), “Vitamin D and bone mineral density status, and their correlation with bone turnover markers in healthy children aged 6–14 in Vietnam”, Curr Pediatr Res, 24(3), pp. 203-208
13. Turkeli. A, Ayaz. O, Uncu. A, et al. (2016), “Effects of vitamin D levels on asthma control and severity in pre-school children”, Eur Rev Med Pharmacol Sci, 20(1), pp.26-36.
14. Uysalol M, Mutlu LC, Saracoglu GV, et al. (2013), “Childhood asthma and vitamin D deficiency in Turkey: Is there cause and effect relationship between them”, Ital J Pediatr, 39, pp.78.