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STUDY ON ISOLATION OF TWO AROMATIC MONOCYCLIC DERIVATIVES FROM LICHEN USNEA UNDULATA STIRTON (PARMELIACEAE)
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Abstract
Background: Rate of increase of antibiotic resistance is one of the biggest threats to global health. Screening for new and alternative antibiotics of natural origin is an urgent demand. Lichen aromatic monocyclic derivatives have been exhibited significantly antimicrobial activity. As part of our studies on antibacterial activity of Vietnamese lichens, a project "Study on isolation of aromatic monocyclic derivatives from lichen Usnea Undulata" was performed. Objectives: To isolate and determine the structure of some aromatic monocyclic derivatives from lichen U. undulata. Material and methods: Lichen U. undulata was collected in Bidoup Nui Ba National Park, Lam Dong province. The extract was prepared by maceration with ultrasonic-assisted. Using column chromatography, thin-layer chromatography, and recrystallization to isolate the pure compounds. The structures of isolated compounds were determined by nuclear magnetic resonance spectroscopy (NMR). Results: From 100g of lichen, 6.12g of acetone extract was obtained. Isolation and determination of structures of two compounds as methyl β orcinolcarboxylate (1) and orsellinic acid (2). Conclusions: The study isolated and determined the structure of two compounds methyl βorcinolcarboxylate and orsellinic acid, contributing to study on the chemical composition of lichens U. undulata collected in Viet Nam.
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Keywords
Lichen, methyl β-orcinolcarboxylate, orsellinic acid, Usnea
References
2. Nguyen Thi Thu Tram , Dinh Hoang Anh , Huynh Hoang Thuc , Nguyen Trong Tuan (2020), “Investigation of chemical constituents and cytotoxic activity of the lichen Usnea undulata” ,Vietnam J. Chem, 58(1), 63
3. Trung Do, Trang T.H. Nguyen, Thai N. Ha, Nguyen T.H. Nhu, Nguyen Van Lam, Nguyen T.T. Tram, and Yen Pham (2019), “Identification of Anti-Helicobacter pylori Compounds From Usnea undulata”, Natural Product Communications, pp.1-3.
4. Tram Thi Thu Nguyen, Trinh Thi Diem Vo, Yen Hoang Tran, Dat Tuan Truong, Duy Chi Phan, Phuoc Huu Le (2021), “Photoprotective Activity of Lichen Extracts and Isolated Compounds in Parmotrema Tinctorum”, Biointerface Research in Applied Chemistry, Volume 11, Issue 5, 12653-12661.
5. Duong Thuc Huy (2015), “Study on chemical constituents and biological activities of four lichens growing in the South of Vietnam”, PhD thesis, Vietnam National University, Ho Chi Minh City, University of Science.
6. Prashith Kekuda TR, Mesta AR, Vinayaka KS, Darshini SM and Akarsh S, (2016), “Antimicrobial Activity of Usnea ghattensis G. Awasthi and Usnea undulata Stirt”, Journal of Chemical and Pharmaceutical Research, 8(12), 83-88.
7. Thiago I.B.L., Roberta G.C, Nídia C.Y, et al. (2008), “Radical-scavenging activity of orsellinates”, Chem. Pharm. Bull. , 56, pp.1551-1554.
8. Huneck S. and Yoshimura I. (1996), Identification of lichen substances. Springer, 160-163.
9. Pathak, Ashutosh (2017), “Potenial of methyl- β-orcinolcarboxylate as antibiofilm agent: an in silico study”, Pharma Science Monitor, Vol. 8 Issue 3, 305-315.
10. Vinitha M. Thadhan and Veranja Karunaratne (2017), Potential of Lichen Compounds as Antidiabetic Agents with Antioxidative Properties: A Review, Hindawi Oxidative Medicine and Cellular Longevity Volume 2017, Article ID 2079697, 1-11.