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HAIR BIOLOGY, RESEARCH MODELS AND EVALUATION OF HAIR REGROWTH IN IN-VITRO AND IN-VIVO - A REVIEW
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Abstract
Background: Hair, representing individuality, has been widely recognized as a pivotal element in crafting a distinctive image and overall allure for individuals. Consequently, hair care transcends mere aesthetics, constituting an essential aspect of self-assurance and personal growth. In this context, research on hair loss and regrowth attracted the attention of many researchers for two main reasons. Firstly, hair loss was one of the common dermatological issues, and secondly, the existing treatment approaches were still constrained and showed divergent success rates. Typically, minoxidil and finasteride emerged as the primary agents in such treatments. Additionally, the use of herbal remedies such as Citrus grandis, Polygoum multiflorum, Gleditsia fera, and Rosmarinus officinalis to support hair growth has been increasingly popular. To demonstrate the effectiveness of treatment methods while minimizing unwanted reactions, these studies were often conducted on animals such as mice, rats, rabbits, sheep. Of these, mice and rats were particularly suitable due to their genetic similarity and shorter lifespan compared to other animal species. Conclusions: This research enhanced our comprehension of the physiological mechanisms governing hair, including its growth and shedding cycles. Through the utilization of appropriate animal models, we were able to assess hair regrowth status both in vitro and in vivo, thus accumulating insights for potential human applications.
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Keywords
Hair biology, hair regrowth, in-vitro, in-vivo
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